ID   PC-10
AC   CVCL_7088
SY   PC 10; PC10
DR   BTO; BTO_0004886
DR   EFO; EFO_0002843
DR   cancercelllines; CVCL_7088
DR   CGH-DB; 190-1
DR   CGH-DB; 9175-4
DR   ChEMBL-Cells; CHEMBL3307345
DR   ChEMBL-Targets; CHEMBL614234
DR   Cosmic; 713859
DR   Cosmic; 801575
DR   Cosmic; 844813
DR   Cosmic; 876168
DR   Cosmic; 917999
DR   Cosmic; 929155
DR   Cosmic; 1089228
DR   Cosmic; 1219087
DR   Cosmic; 1239915
DR   Cosmic; 1571736
DR   Cosmic; 2125280
DR   Cosmic; 2668325
DR   IARC_TP53; 2383
DR   PubChem_Cell_line; CVCL_7088
DR   Wikidata; Q54938387
RX   PubMed=758928;
RX   PubMed=3731100;
RX   PubMed=8263009;
RX   PubMed=8385084;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=11583962;
RX   PubMed=12794755;
RX   PubMed=14581340;
RX   PubMed=15185009;
RX   PubMed=15746151;
RX   PubMed=17511773;
RX   PubMed=19472407;
RX   PubMed=20557307;
RX   PubMed=23381221;
RX   PubMed=25120651;
CC   From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified (PubMed=8263009; PubMed=10536175; PubMed=12794755; PubMed=20557307).
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=758928; DOI=10.1038/bjc.1979.3; PMCID=PMC2009802;
RA   Kinjo M., Oka K., Naito S., Kohga S., Tanaka K., Oboshi S., Hayata Y.,
RA   Yasumoto K.;
RT   "Thromboplastic and fibrinolytic activities of cultured human cancer
RT   cell lines.";
RL   Br. J. Cancer 39:15-23(1979).
//
RX   PubMed=3731100;
RA   Hanai N., Shitara K., Yoshida H.;
RT   "Generation of monoclonal antibodies against human lung squamous cell
RT   carcinoma and adenocarcinoma using mice rendered tolerant to normal
RT   human lung.";
RL   Cancer Res. 46:4438-4443(1986).
//
RX   PubMed=8263009; DOI=10.1007/BF01202192;
RA   Kashii T., Mizushima Y., Monno S., Nakagawa K., Kobayashi M.;
RT   "Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility
RT   genes in human lung cancer cell lines by the polymerase chain
RT   reaction/single-strand conformation polymorphism method.";
RL   J. Cancer Res. Clin. Oncol. 120:143-148(1994).
//
RX   PubMed=8385084; DOI=10.1111/j.1349-7006.1993.tb02851.x; PMCID=PMC5919128;
RA   Suzuki S., Takahashi T., Nakamura S., Koike K., Ariyoshi Y.,
RA   Takahashi T., Ueda R.;
RT   "Alterations of integrin expression in human lung cancer.";
RL   Jpn. J. Cancer Res. 84:168-174(1993).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=11583962; DOI=10.1016/S0002-9440(10)62521-7; PMCID=PMC1850523;
RA   Haruki N., Harano T., Masuda A., Kiyono T., Takahashi T.,
RA   Tatematsu Y., Shimizu S., Mitsudomi T., Konishi H., Osada H.,
RA   Fujii Y., Takahashi T.;
RT   "Persistent increase in chromosome instability in lung cancer:
RT   possible indirect involvement of p53 inactivation.";
RL   Am. J. Pathol. 159:1345-1352(2001).
//
RX   PubMed=12794755; DOI=10.1002/ijc.11184;
RA   Endoh H., Yatabe Y., Shimizu S., Tajima K., Kuwano H., Takahashi T.,
RA   Mitsudomi T.;
RT   "RASSF1A gene inactivation in non-small cell lung cancer and its
RT   clinical implication.";
RL   Int. J. Cancer 106:45-51(2003).
//
RX   PubMed=14581340;
RA   Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.;
RT   "TERC identified as a probable target within the 3q26 amplicon that is
RT   detected frequently in non-small cell lung cancers.";
RL   Clin. Cancer Res. 9:4705-4713(2003).
//
RX   PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254;
RA   Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H.,
RA   Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T.,
RA   Fujisawa T.;
RT   "Correlation between interleukin 6 production and tumor proliferation
RT   in non-small cell lung cancer.";
RL   Cancer Immunol. Immunother. 53:786-792(2004).
//
RX   PubMed=15746151; DOI=10.1093/hmg/ddi092;
RA   Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M.,
RA   Hirohashi S., Inazawa J., Imoto I.;
RT   "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in
RT   non-small cell lung cancers.";
RL   Hum. Mol. Genet. 14:997-1007(2005).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702;
RA   Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y.,
RA   Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K.,
RA   Yasumoto K.;
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.;
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=23381221; DOI=10.3892/or.2013.2266; PMCID=PMC3621652;
RA   Suzuki M., Shiraishi K., Eguchi A., Ikeda K., Mori T., Yoshimoto K.,
RA   Ohba Y., Yamada T., Ito T., Baba Y., Baba H.;
RT   "Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small
RT   cell lung cancer.";
RL   Oncol. Rep. 29:1308-1314(2013).
//
RX   PubMed=25120651; DOI=10.3892/ol.2014.2234; PMCID=PMC4114630;
RA   Suzuki M., Ikeda K., Shiraishi K., Eguchi A., Mori T., Yoshimoto K.,
RA   Shibata H., Ito T., Baba Y., Baba H.;
RT   "Aberrant methylation and silencing of IRF8 expression in non-small
RT   cell lung cancer.";
RL   Oncol. Lett. 8:1025-1030(2014).
//