ID   Lec15.1
AC   CVCL_7054
AS   CVCL_DD08
SY   CHO Lec15.1; Lec15.1 CHO; B4-2-1; B421
DR   BTO; BTO_0002430
DR   Wikidata; Q54902422
RX   PubMed=1986234;
RX   PubMed=2105319;
RX   PubMed=2267628;
RX   PubMed=6270122;
RX   PubMed=9753618;
RX   PubMed=14680801;
RX   PubMed=20331963;
CC   Sequence variation: Mutation; UniProtKB; Q9Z1P1; Dpm2; Simple; p.Gly10Glu (c.29G>A); Zygosity=Unspecified (PubMed=14680801).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_DD06 ! N211-1-8
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 15
//
RX   PubMed=1986234; DOI=10.1128/mcb.11.1.391-400.1991; PMCID=PMC359638;
RA   Singh N., Tartakoff A.M.;
RT   "Two different mutants blocked in synthesis of
RT   dolichol-phosphoryl-mannose do not add glycophospholipid anchors to
RT   membrane proteins: quantitative correction of the phenotype of a CHO
RT   cell mutant with tunicamycin.";
RL   Mol. Cell. Biol. 11:391-400(1991).
//
RX   PubMed=2105319; DOI=10.1016/S0021-9258(19)39975-2;
RA   Zeng Y.-C., Lehrman M.A.;
RT   "A block at Man5GlcNAc2-pyrophosphoryldolichol in intact but not
RT   disrupted castanospermine and swainsonine-resistant Chinese hamster
RT   ovary cells.";
RL   J. Biol. Chem. 265:2296-2305(1990).
//
RX   PubMed=2267628; DOI=10.1007/BF01233094;
RA   Beck P.J., Gething M.-J., Sambrook J.F., Lehrman M.A.;
RT   "Complementing mutant alleles define three loci involved in
RT   mannosylation of Man5-GlcNAc2-P-P-dolichol in Chinese hamster ovary
RT   cells.";
RL   Somat. Cell Mol. Genet. 16:539-548(1990).
//
RX   PubMed=6270122; DOI=10.1016/S0021-9258(19)68668-0;
RA   Robbins A.R., Myerowitz R., Youle R.J., Murray G.J., Neville D.M. Jr.;
RT   "The mannose 6-phosphate receptor of Chinese hamster ovary cells.
RT   Isolation of mutants with altered receptors.";
RL   J. Biol. Chem. 256:10618-10622(1981).
//
RX   PubMed=9753618; DOI=10.1006/bbrc.1998.9304;
RA   Walker B.K., Lei H., Krag S.S.;
RT   "A functional link between N-linked glycosylation and apoptosis in
RT   Chinese hamster ovary cells.";
RL   Biochem. Biophys. Res. Commun. 250:264-270(1998).
//
RX   PubMed=14680801; DOI=10.1016/j.bbrc.2003.10.152;
RA   Pu L.-X., Scocca J.R., Walker B.K., Krag S.S.;
RT   "A single point mutation resulting in an adversely reduced expression
RT   of DPM2 in the Lec15.1 cells.";
RL   Biochem. Biophys. Res. Commun. 312:555-561(2003).
//
RX   PubMed=20331963; DOI=10.1016/j.bbrc.2010.03.117; PMCID=PMC2887678;
RA   Jones M.B., Tomiya N., Betenbaugh M.J., Krag S.S.;
RT   "Analysis and metabolic engineering of lipid-linked oligosaccharides
RT   in glycosylation-deficient CHO cells.";
RL   Biochem. Biophys. Res. Commun. 395:36-41(2010).
//