ID   BLM
AC   CVCL_7035
SY   BRO Lung Metastasis
DR   BTO; BTO_0002803
DR   cancercelllines; CVCL_7035
DR   Cosmic; 808558
DR   Cosmic; 1132580
DR   Cosmic; 1181767
DR   Cosmic; 2036700
DR   GEO; GSM1507940
DR   Wikidata; Q54797375
RX   PubMed=1918136;
RX   PubMed=2060184;
RX   PubMed=25502142;
RX   PubMed=25728708;
RX   PubMed=26550137;
CC   Population: Caucasian.
CC   Characteristics: Obtained by injection of parent cell line in nude mice and selection of cells from lung metastases.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=25728708).
CC   Omics: Transcriptomics; RNAseq.
CC   Misspelling: BML; Cosmic=1132580.
CC   Derived from site: In situ; Shoulder, skin; UBERON=UBERON_0001483.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7036 ! BRO
SX   Male
AG   34Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 16
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RX   PubMed=1918136; DOI=10.1083/jcb.115.1.191; PMCID=PMC2289921;
RA   Quax P.H.A., van Muijen G.N.P., Weening-Verhoeff E.J.D., Lund L.R.,
RA   Dano K., Ruiter D.J., Verheijen J.H.;
RT   "Metastatic behavior of human melanoma cell lines in nude mice
RT   correlates with urokinase-type plasminogen activator, its type-1
RT   inhibitor, and urokinase-mediated matrix degradation.";
RL   J. Cell Biol. 115:191-199(1991).
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RX   PubMed=2060184; DOI=10.1007/BF01753729;
RA   van Muijen G.N.P., Cornelissen I.L.M.H.A., Jansen K.F.J., Figdor C.G.,
RA   Johnson J.P., Brocker E.-B., Ruiter D.J.;
RT   "Antigen expression of metastasizing and non-metastasizing human
RT   melanoma cells xenografted into nude mice.";
RL   Clin. Exp. Metastasis 9:259-272(1991).
//
RX   PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333;
RA   Muller J., Krijgsman O., Tsoi J., Robert L., Hugo W., Song C.,
RA   Kong X.-J., Possik P.A., Cornelissen-Steijger P.D.M., Geukes Foppen M.H.,
RA   Kemper K., Goding C.R., McDermott U., Blank C., Haanen J.B.A.G.,
RA   Graeber T.G., Ribas A., Lo R.S., Peeper D.S.;
RT   "Low MITF/AXL ratio predicts early resistance to multiple targeted
RT   drugs in melanoma.";
RL   Nat. Commun. 5:5712.1-5712.15(2014).
//
RX   PubMed=25728708; DOI=10.1111/pcmr.12364;
RA   Vogel C.J., Smit M.A., Maddalo G., Possik P.A., Sparidans R.W.,
RA   van der Burg S.H., Verdegaal E.M.E., Heck A.J.R., Samatar A.A.,
RA   Beijnen J.H., Altelaar A.F.M., Peeper D.S.;
RT   "Cooperative induction of apoptosis in NRAS mutant melanoma by
RT   inhibition of MEK and ROCK.";
RL   Pigment Cell Melanoma Res. 28:307-317(2015).
//
RX   PubMed=26550137; PMCID=PMC4612822;
RA   Leder D.C., Brown J.R., Ramaraj P.;
RT   "In-vitro rescue and recovery studies of human melanoma (BLM) cell
RT   growth, adhesion and migration functions after treatment with
RT   progesterone.";
RL   Int. J. Clin. Exp. Med. 8:12275-12285(2015).
//