ID   BEP2D
AC   CVCL_6E77
DR   GEO; GSM3611827
DR   GEO; GSM3611828
DR   GEO; GSM3611829
DR   Wikidata; Q54796049
RX   DOI=10.1007/978-1-4612-0411-4_11;
RX   DOI=10.3760/cma.j.issn.0254-5098.2003.04.001;
RX   PubMed=1717149;
RX   PubMed=8118924;
RX   PubMed=9214610;
RX   PubMed=10426802;
RX   PubMed=10657959;
RX   PubMed=11538954;
RX   PubMed=12548635;
RX   PubMed=24944801;
RX   PubMed=31158229;
CC   Doubling time: 35 hours (PubMed=8118924).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
ST   Source(s): PubMed=31158229
ST   Amelogenin: X,Y
ST   CSF1PO: 9,12
ST   D10S1248: 14,15
ST   D12S391: 17,18
ST   D13S317: 13
ST   D16S539: 12
ST   D18S51: 18,19
ST   D19S433: 13.2,15.2
ST   D1S1656: 14
ST   D21S11: 28,30
ST   D22S1045: 14,16
ST   D2S1338: 22,23
ST   D2S441: 11,11.3
ST   D3S1358: 15,17
ST   D5S818: 12,13
ST   D6S1043: 12,18
ST   D7S820: 10,13
ST   D8S1179: 13,15
ST   DYS391: 10
ST   FGA: 20,24
ST   Penta D: 2.2,13
ST   Penta E: 5,8
ST   SE33: 20.2,28.2
ST   TH01: 7,9.3
ST   TPOX: 6,11
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B4IR ! BEP1B
OI   CVCL_6E78 ! BEP3D
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 23-02-16; Last updated: 10-04-25; Version: 10
//
RX   DOI=10.1007/978-1-4612-0411-4_11;
RA   Willey J.C., Greene J., Bressoud A., Cerutti P.A., Hei T.K., Wang N.,
RA   Maillie D., Cox C., Miles E.;
RT   "Effects of ionizing radiation on human papillomavirus immortalized
RT   human bronchial epithelial cells.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.113-117; Humana Press; New York; USA (1990).
//
RX   DOI=10.3760/cma.j.issn.0254-5098.2003.04.001;
RA   Fan B.-X., Zhang K.-T., Sun J.-F., Xiang X.-Q., Xie L., Hu Y.-C.,
RA   Wang S.-Q., Wu D.-C.;
RT   "Identification of differentially expressed genes in different
RT   malignant transformation phases of BEP2D cell line.";
RL   Zhonghua Fang She Yi Xue Yu Fang Hu Za Zhi 23:231-233(2003).
//
RX   PubMed=1717149;
RA   Willey J.C., Bressoud A., Sleemi A., Bennett W.P., Cerutti P.A.,
RA   Harris C.C.;
RT   "Immortalization of normal human bronchial epithelial cells by human
RT   papillomaviruses 16 or 18.";
RL   Cancer Res. 51:5370-5377(1991).
//
RX   PubMed=8118924; DOI=10.1093/carcin/15.3.431;
RA   Hei T.K., Piao C.Q., Willey J.C., Sutter T., Hall E.J.;
RT   "Malignant transformation of human bronchial epithelial cells by
RT   radon-simulated alpha-particles.";
RL   Carcinogenesis 15:431-437(1994).
//
RX   PubMed=9214610; DOI=10.1093/carcin/18.6.1251;
RA   Weaver D.A., Hei T.K., Hukku B., McRaven J.A., Willey J.C.;
RT   "Cytogenetic and molecular genetic analysis of tumorigenic human
RT   bronchial epithelial cells induced by radon alpha particles.";
RL   Carcinogenesis 18:1251-1257(1997).
//
RX   PubMed=10426802; DOI=10.1093/carcin/20.8.1529;
RA   Piao C.Q., Willey J.C., Hei T.K.;
RT   "Alterations of p53 in tumorigenic human bronchial epithelial cells
RT   correlate with metastatic potential.";
RL   Carcinogenesis 20:1529-1533(1999).
//
RX   PubMed=10657959; DOI=10.1093/carcin/21.2.205;
RA   Weaver D.A., Hei T.K., Hukku B., DeMuth J.P., Crawford E.L.,
RA   McRaven J.A., Girgis S., Willey J.C.;
RT   "Localization of tumor suppressor gene candidates by cytogenetic and
RT   short tandem repeat analyses in tumorigenic human bronchial
RT   epithelial cells.";
RL   Carcinogenesis 21:205-211(2000).
//
RX   PubMed=11538954; DOI=10.1016/0273-1177(95)00800-t;
RA   Hei T.K., Piao C.Q., Sutter T., Willey J.C., Suzuki K.;
RT   "Cellular and molecular alterations in human epithelial cells
RT   transformed by high LET radiation.";
RL   Adv. Space Res. 18:137-148(1996).
//
RX   PubMed=12548635; DOI=10.1002/pmic.200390010;
RA   Ying W.-T., Zhang K.-T., Qian X.-H., Xie L., Wang J., Xiang X.-Q.,
RA   Cai Y., Wu D.-C.;
RT   "Proteome analysis on an early transformed human bronchial epithelial
RT   cell line, BEP2D, after alpha-particle irradiation.";
RL   Proteomics 3:64-72(2003).
//
RX   PubMed=24944801; DOI=10.3892/br.2014.268; PMCID=PMC4051483;
RA   Liu C.-Y., Li P., Gao D.-W., Zhou P.-K., Shao Y., Zhang Q., Li W.-B.;
RT   "Abnormal promoter methylation of multiple tumor suppressor genes in
RT   human bronchial epithelial malignant cells.";
RL   Biomed. Rep. 2:525-528(2014).
//
RX   PubMed=31158229; DOI=10.1371/journal.pone.0213047; PMCID=PMC6546236;
RA   Liu Q.-W., Li H., You L.-K., Li T., Li L.-L., Zhou P.-K., Bo X.-C.,
RA   Chen H.-B., Chen X.-H., Hu Y.;
RT   "Genome-wide identification and analysis of A-to-I RNA editing events
RT   in the malignantly transformed cell lines from bronchial epithelial
RT   cell line induced by alpha-particles radiation.";
RL   PLoS ONE 14:e0213047.1-e0213047.14(2019).
//