ID   T4-PA
AC   CVCL_6C60
DR   ABM; T8148
DR   Wikidata; Q54971543
RX   PubMed=26254261;
CC   Characteristics: Highly metastatic. Produces widespread metastatic lesions throughout the bodies of nude NIH Swiss mice when injected intravenously. Obtained by injection of parent cell line (T3-HA) in the tail vein of nude NIH Swiss mice and selection of cells from a lung metastasis.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
CC   Cell type: Fibroblast; CL=CL_0000057.
CC   Breed/subspecies: NIH Swiss.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_6C59 ! T3-HA
SX   Male
AG   Embryo
CA   Transformed cell line
DT   Created: 23-02-16; Last updated: 10-04-25; Version: 11
//
RX   PubMed=26254261; DOI=10.1016/j.yexcr.2015.07.029;
RA   Ray, Durwood B.
RA   Merrill, Gerald A.
RA   Brenner, Frederic J.
RA   Lytle, Laurie S.
RA   Lam, Tan
RA   McElhinney, Aaron
RA   Anders, Joel
RA   Rock, Tara Tauber
RA   Lyker, Jennifer Kier
RA   Barcus, Scott
RA   Leslie, Kara Hust
RA   Kramer, Jill M.
RA   Rubenstein, Eric M.
RA   Pryor Schanz, Karen
RA   Parkhurst, Amy J.
RA   Peck, Michelle
RA   Good, Kimberly
RA   Granath, Kristi Lemke
RA   Cifra, Nicole
RA   Detweiler, Jessalee Wantz
RA   Stevens, Laura
RA   Albertson, Richard
RA   Deir, Rachael
RA   Stewart, Elisabeth
RA   Wingard, Katherine
RA   Richardson, Micah Rose
RA   Blizard, Sarah B.
RA   Gillespie, Lauren E.
RA   Kriley, Charles E.
RA   Rzewnicki, Daniel I.
RA   Jones, David H.
RT   "T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial
RT   tumorigenic in vitro/in vivo passages give rise to increasingly
RT   aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell
RT   lines T3-HA and T4-PA.";
RL   Exp. Cell Res. 340:1-11(2016).
//