ID   QG-56
AC   CVCL_6943
SY   QG 56; QG56
DR   EFO; EFO_0002848
DR   cancercelllines; CVCL_6943
DR   CCRID; 3101HUMTCHu92
DR   ChEMBL-Cells; CHEMBL3307796
DR   ChEMBL-Targets; CHEMBL612268
DR   Cosmic; 1336876
DR   Cosmic; 1571741
DR   Cosmic; 2645026
DR   Cosmic; 2664121
DR   IARC_TP53; 18792
DR   PubChem_Cell_line; CVCL_6943
DR   Wikidata; Q54948814
RX   DOI=10.2995/jacsurg1987.4.6_755;
RX   PubMed=229054;
RX   PubMed=758928;
RX   PubMed=1737336;
RX   PubMed=1778766;
RX   PubMed=3986962;
RX   PubMed=8385084;
RX   PubMed=8752176;
RX   PubMed=9023415;
RX   PubMed=9538136;
RX   PubMed=11583962;
RX   PubMed=12569360;
RX   PubMed=12794755;
RX   PubMed=17131342;
RX   PubMed=17511773;
RX   PubMed=19799608;
CC   Population: Japanese.
CC   HLA typing: A*26:01; B*46:01; C*01:02 (PubMed=9023415).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (PubMed=12794755).
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
//
RX   DOI=10.2995/jacsurg1987.4.6_755;
RA   Uchida T., Imaizumi M., Sakakibara M., Abe T.;
RT   "Interaction between fibroblasts and lung cancer cells at nodal
RT   involvement.";
RL   Nihon Kokyuki Geka Gakkai Zasshi 4:755-759(1990).
//
RX   PubMed=229054; DOI=10.20772/cancersci1959.70.4_533;
RA   Yanagawa E., Yasumoto K., Manabe H., Nagano N., Hirota N., Ohta M.,
RA   Hattori T., Nomoto K., Azuma I., Yamamura Y.;
RT   "Cytostatic activity of peripheral blood monocytes against
RT   bronchogenic carcinoma cells in patients with lung cancer.";
RL   Gann 70:533-539(1979).
//
RX   PubMed=758928; DOI=10.1038/bjc.1979.3; PMCID=PMC2009802;
RA   Kinjo M., Oka K., Naito S., Kohga S., Tanaka K., Oboshi S., Hayata Y.,
RA   Yasumoto K.;
RT   "Thromboplastic and fibrinolytic activities of cultured human cancer
RT   cell lines.";
RL   Br. J. Cancer 39:15-23(1979).
//
RX   PubMed=1737336;
RA   Yoshino I., Yano T., Murata M., Ishida T., Sugimachi K., Kimura G.,
RA   Nomoto K.;
RT   "Tumor-reactive T-cells accumulate in lung cancer tissues but fail to
RT   respond due to tumor cell-derived factor.";
RL   Cancer Res. 52:775-781(1992).
//
RX   PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361;
RA   Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M.,
RA   Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.;
RT   "Aberrant elevation of tyrosine-specific phosphorylation in human
RT   gastric cancer cells.";
RL   Jpn. J. Cancer Res. 82:1428-1435(1991).
//
RX   PubMed=3986962; DOI=10.1093/carcin/6.4.549;
RA   Watatani M., Ikenaga M., Hatanaka T., Kinuta M., Takai S.-i., Mori T.,
RA   Kondo S.;
RT   "Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA
RT   damage in tumor cell strains from Japanese patients and demonstration
RT   of MNNG hypersensitivity of Mer xenografts in athymic nude mice.";
RL   Carcinogenesis 6:549-553(1985).
//
RX   PubMed=8385084; DOI=10.1111/j.1349-7006.1993.tb02851.x; PMCID=PMC5919128;
RA   Suzuki S., Takahashi T., Nakamura S., Koike K., Ariyoshi Y.,
RA   Takahashi T., Ueda R.;
RT   "Alterations of integrin expression in human lung cancer.";
RL   Jpn. J. Cancer Res. 84:168-174(1993).
//
RX   PubMed=8752176;
RA   Iguchi H., Tanaka S., Ozawa Y., Kashiwakuma T., Kimura T., Hiraga T.,
RA   Ozawa H., Kono A.;
RT   "An experimental model of bone metastasis by human lung cancer cells:
RT   the role of parathyroid hormone-related protein in bone metastasis.";
RL   Cancer Res. 56:4040-4043(1996).
//
RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.;
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//
RX   PubMed=9538136; DOI=10.3892/ijo.12.5.1103;
RA   Takaki T., Hiraki A., Uenaka A., Gomi S., Itoh K., Udono H.,
RA   Shibuya A., Tsuji T., Sekiguchi S., Nakayama E.;
RT   "Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3
RT   peptide recognized by cytotoxic T lymphocytes.";
RL   Int. J. Oncol. 12:1103-1109(1998).
//
RX   PubMed=11583962; DOI=10.1016/S0002-9440(10)62521-7; PMCID=PMC1850523;
RA   Haruki N., Harano T., Masuda A., Kiyono T., Takahashi T.,
RA   Tatematsu Y., Shimizu S., Mitsudomi T., Konishi H., Osada H.,
RA   Fujii Y., Takahashi T.;
RT   "Persistent increase in chromosome instability in lung cancer:
RT   possible indirect involvement of p53 inactivation.";
RL   Am. J. Pathol. 159:1345-1352(2001).
//
RX   PubMed=12569360; DOI=10.1038/sj.onc.1206106;
RA   Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y.,
RA   Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T.,
RA   Hayashi S., Aozasa K., Kawase I.;
RT   "Expression of tetraspanins in human lung cancer cells: frequent
RT   downregulation of CD9 and its contribution to cell motility in small
RT   cell lung cancer.";
RL   Oncogene 22:674-687(2003).
//
RX   PubMed=12794755; DOI=10.1002/ijc.11184;
RA   Endoh H., Yatabe Y., Shimizu S., Tajima K., Kuwano H., Takahashi T.,
RA   Mitsudomi T.;
RT   "RASSF1A gene inactivation in non-small cell lung cancer and its
RT   clinical implication.";
RL   Int. J. Cancer 106:45-51(2003).
//
RX   PubMed=17131342; DOI=10.1002/ijc.22396;
RA   Sugaya M., Takenoyama M., Shigematsu Y., Baba T., Fukuyama T.,
RA   Nagata Y., Mizukami M., So T., Ichiki Y., Yasuda M., So T.,
RA   Hanagiri T., Sugio K., Yasumoto K.;
RT   "Identification of HLA-A24 restricted shared antigen recognized by
RT   autologous cytotoxic T lymphocytes from a patient with large cell
RT   carcinoma of the lung.";
RL   Int. J. Cancer 120:1055-1062(2007).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702;
RA   Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y.,
RA   Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K.,
RA   Yasumoto K.;
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=19799608; DOI=10.1111/j.1349-7006.2009.01351.x; PMCID=PMC11159900;
RA   Kuroda K., Takenoyama M., Baba T., Shigematsu Y., Shiota H.,
RA   Ichiki Y., Yasuda M., Uramoto H., Hanagiri T., Yasumoto K.;
RT   "Identification of ribosomal protein L19 as a novel tumor antigen
RT   recognized by autologous cytotoxic T lymphocytes in lung
RT   adenocarcinoma.";
RL   Cancer Sci. 101:46-53(2010).
//