ID DiFi AC CVCL_6895 SY DIFI DR BTO; BTO_0005902 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 856 DR cancercelllines; CVCL_6895 DR Cell_Model_Passport; SIDM00049 DR Cosmic; 1479628 DR Cosmic; 1519358 DR Cosmic; 2841360 DR Cosmic-CLP; 1789883 DR DepMap; ACH-002233 DR EGA; EGAS00001000978 DR GDSC; 1789883 DR GEO; GSM1448175 DR GEO; GSM1669732 DR KCB; KCB 2014033YJ DR PharmacoDB; DIFI_291_2019 DR PRIDE; PXD005235 DR PRIDE; PXD030304 DR PubChem_Cell_line; CVCL_6895 DR Wikidata; Q54831091 RX DOI=10.1007/978-4-431-68337-7_80; RX PubMed=8385096; RX PubMed=20570890; RX PubMed=22270724; RX PubMed=22722830; RX PubMed=25623215; RX PubMed=25926053; RX PubMed=27397505; RX PubMed=28854368; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Caucasian. CC Doubling time: ~40 hours (PubMed=8385096). CC Microsatellite instability: Stable (MSS) (PubMed=25926053; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu443fs*16 (c.1328_1329delAA); Zygosity=Heterozygous (Cosmic-CLP=1789883; DepMap=ACH-002233). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1151Ter (c.3451G>T); Zygosity=Heterozygous (Cosmic-CLP=1789883; DepMap=ACH-002233). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (Cosmic-CLP=1789883; DepMap=ACH-002233). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; PTM; Phosphorylation; Quantitative. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Genome ancestry: African=2.91%; Native American=0.44%; East Asian, North=1.85%; East Asian, South=0%; South Asian=0%; European, North=54.25%; European, South=40.55% (PubMed=30894373). CC Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0002000000030). It was one of the sources for the STR profile of this entry. CC Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. ST Source(s): CCRID; Cosmic-CLP=1789883; PubMed=25926053 ST Amelogenin: X ST CSF1PO: 10,11 ST D13S317: 8,11 ST D16S539: 12 ST D18S51: 13 ST D21S11: 32 ST D3S1358: 17,18 ST D5S818: 11,12 ST D7S820: 10,12 ST D8S1179: 12 ST FGA: 23,27 ST Penta D: 12 ST Penta E: 12,18 ST TH01: 7,9.3 ST TPOX: 8,9 ST vWA: 17,18 DI NCIt; C2955; Colorectal carcinoma DI NCIt; C6728; Gardner syndrome DI ORDO; Orphanet_79665; Gardner syndrome OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 46Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 33 CH CVCL_EI68 ! DCR10 CH CVCL_EI69 ! DCR7 CH CVCL_EI70 ! DCR9 CH CVCL_A2BW ! DiFi R1 Cetux CH CVCL_A2BX ! DiFi R2 Cetux // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514; RA Janakiraman, Manickam RA Vakiani, Efsevia RA Zeng, Zhao-Shi RA Pratilas, Christine A. RA Taylor, Barry Stephen RA Chitale, Dhananjay RA Halilovic, Ensar RA Wilson, Manda RA Huberman, Kety RA Ricarte Filho, Julio Cezar Marques RA Persaud, Yogindra RA Levine, Douglas A. RA Fagin, James Alexander RA Jhanwar, Suresh C. RA Mariadason, John M. RA Lash, Alex RA Ladanyi, Marc RA Saltz, Leonard B. RA Heguy, Adriana RA Paty, Philip B. RA Solit, David B. RT "Genomic and biological characterization of exon 4 KRAS mutations in RT human cancer."; RL Cancer Res. 70:5901-5911(2010). // RX DOI=10.1007/978-4-431-68337-7_80; RA Boman, Bruce Millring RA Olive, Matilde RA Untawale, Seema RA Blick, Mark RA North, Susan RA Gallick, Gary E. RA Dolf, Gaudenz RA Siciliano, Michael Joseph RA Roubein, Leor David RA Fritche, Herbert RA Thomas, Gilles RA Pathak, Sen RA Wildrick, David M. RA Levin, Bernard RT "The DiFi rectal carcinoma cell line from a familial adenomatous RT polyposis patient: an in vitro model system to study genetic changes RT in colorectal cancer."; RL (In book chapter) Hereditary colorectal cancer; Utsunomiya, Joji & Lynch, Henry Thompson (eds.); pp.541-548; Springer; Tokyo; Japan (1990). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=22722830; DOI=10.1038/nature11156; PMCID=PMC3927413; RA Misale, Sandra RA Yaeger, Rona D. RA Hobor, Sebastijan RA Scala, Elisa RA Janakiraman, Manickam RA Liska, David RA Valtorta, Emanuele RA Schiavo, Roberta RA Buscarino, Michela RA Siravegna, Giulia RA Bencardino, Katia Bruna RA Cercek, Andrea RA Chen, Chin-Tung RA Veronese, Silvio RA Zanon, Carlo RA Sartore-Bianchi, Andrea RA Gambacorta, Marcello RA Gallicchio, Margherita RA Vakiani, Efsevia RA Boscaro, Valentina RA Medico, Enzo RA Weiser, Martin R. RA Siena, Salvatore RA Di Nicolantonio, Federica RA Solit, David B. RA Bardelli, Alberto RT "Emergence of KRAS mutations and acquired resistance to anti-EGFR RT therapy in colorectal cancer."; RL Nature 486:532-536(2012). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=8385096; DOI=10.1007/BF02634191; RA Olive, Matilde RA Untawale, Seema RA Coffey, Robert J. RA Siciliano, Michael Joseph RA Wildrick, David M. RA Fritsche, Herbert RA Pathak, Sen RA Cherry, Lorraine M. RA Blick, Mark RA Lointier, Patrice RA Roubein, Leor David RA Levin, Bernard RA Boman, Bruce Millring RT "Characterization of the DiFi rectal carcinoma cell line derived from RT a familial adenomatous polyposis patient."; RL In Vitro Cell. Dev. Biol. Anim. 29:239-248(1993). // RX PubMed=25926053; DOI=10.1038/ncomms8002; RA Medico, Enzo RA Russo, Mariangela RA Picco, Gabriele RA Cancelliere, Carlotta RA Valtorta, Emanuele RA Corti, Giorgio RA Buscarino, Michela RA Isella, Claudio RA Lamba, Simona RA Martinoglio, Barbara RA Veronese, Silvio RA Siena, Salvatore RA Sartore-Bianchi, Andrea RA Beccuti, Marco RA Mottolese, Marcella RA Linnebacher, Michael RA Cordero, Francesca RA Di Nicolantonio, Federica RA Bardelli, Alberto RT "The molecular landscape of colorectal cancer cell lines unveils RT clinically actionable kinase targets."; RL Nat. Commun. 6:7002.1-7002.10(2015). // RX PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821; RA Arena, Sabrina RA Bellosillo, Beatriz RA Siravegna, Giulia RA Martinez, Alejandro RA Canadas, Israel RA Lazzari, Luca RA Ferruz, Noelia RA Russo, Mariangela RA Misale, Sandra RA Gonzalez, Iria RA Iglesias, Mar RA Gavilan, Elena RA Corti, Giorgio RA Hobor, Sebastijan RA Crisafulli, Giovanni RA Salido, Marta RA Sanchez, Juan RA Dalmases, Alba RA Bellmunt, Joaquim RA De Fabritiis, Gianni RA Rovira, Ana RA Di Nicolantonio, Federica RA Albanell, Joan RA Bardelli, Alberto RA Montagut, Clara RT "Emergence of multiple EGFR extracellular mutations during cetuximab RT treatment in colorectal cancer."; RL Clin. Cancer Res. 21:2157-2166(2015). // RX PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010; PMCID=PMC5583477; RA Roumeliotis, Theodoros I. RA Williams, Steven P. RA Goncalves, Emanuel RA Alsinet, Clara RA Del Castillo Velasco-Herrera, Martin RA Aben, Nanne RA Ghavidel, Fatemeh Zamanzad RA Michaut, Magali RA Schubert, Michael RA Price, Stacey RA Wright, James C. RA Yu, Lu RA Yang, Mi RA Dienstmann, Rodrigo RA Guinney, Justin H. RA Beltrao, Pedro RA Brazma, Alvis RA Pardo, Mercedes RA Stegle, Oliver RA Adams, David J. RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Choudhary, Jyoti S. RT "Genomic determinants of protein abundance variation in colorectal RT cancer cells."; RL Cell Rep. 20:2201-2214(2017). // RX PubMed=22270724; DOI=10.1038/nm.2609; RA Montagut, Clara RA Dalmases, Alba RA Bellosillo, Beatriz RA Crespo, Marta RA Pairet, Silvia RA Iglesias, Mar RA Salido, Marta RA Gallen, Manuel RA Marsters, Scot A. RA Tsai, Siao-Ping RA Minoche, Andre E. RA Seshagiri, Somasekar RA Serrano, Sergi RA Himmelbauer, Heinz RA Bellmunt, Joaquim RA Rovira, Ana RA Settleman, Jeffrey RA Bosch, Francesc RA Albanell, Joan RT "Identification of a mutation in the extracellular domain of the RT epidermal growth factor receptor conferring cetuximab resistance in RT colorectal cancer."; RL Nat. Med. 18:221-223(2012). //