ID   DOV13
AC   CVCL_6774
SY   DOV-13; DOV 13
DR   BTO; BTO_0003638
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 859
DR   BioSample; SAMN03470841
DR   BioSample; SAMN10988354
DR   cancercelllines; CVCL_6774
DR   Cell_Model_Passport; SIDM00969
DR   ChEMBL-Cells; CHEMBL3307753
DR   ChEMBL-Targets; CHEMBL615004
DR   Cosmic; 924143
DR   Cosmic; 927565
DR   Cosmic-CLP; 1479987
DR   DepMap; ACH-001063
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 1479987
DR   GEO; GSM659373
DR   GEO; GSM711724
DR   GEO; GSM851916
DR   GEO; GSM1340578
DR   GEO; GSM1341128
DR   GEO; GSM1669743
DR   IARC_TP53; 28278
DR   Millipore; SCC186
DR   PharmacoDB; DOV13_307_2019
DR   PRIDE; PXD003668
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_6774
DR   PubChem_Cell_line; CVCL_6774
DR   Wikidata; Q54831365
RX   PubMed=1536252;
RX   PubMed=7836420;
RX   PubMed=10318951;
RX   PubMed=10972993;
RX   PubMed=16380993;
RX   PubMed=22710073;
RX   PubMed=23415752;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=27561551;
RX   PubMed=30485824;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=31068700;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: African American.
CC   Doubling time: 36.05 hours (JWGray panel).
CC   HLA typing: A*30:02,74:01; B*15:03,51:01; C*02:02,16:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Microsatellite instability: Instable (MSI) (PubMed=31068700).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Ser (c.840A>T); ClinVar=VCV000988616; Zygosity=Heterozygous (DepMap=ACH-001063).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=86.88%; Native American=0.11%; East Asian, North=5.26%; East Asian, South=0%; South Asian=0%; European, North=0%; European, South=7.75% (PubMed=30894373).
CC   Misspelling: DOR 13; ArrayExpress=E-MTAB-2706; PubMed=25485619; PubMed=25877200.
CC   Misspelling: DOR13; PubMed=26589293.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
ST   Source(s): Cosmic-CLP=1479987; Millipore=SCC186; PubMed=22710073; PubMed=25877200; PubMed=30485824; Technion Genomics Center
ST   Amelogenin: X
ST   CSF1PO: 8,10
ST   D10S1248: 13
ST   D12S391: 16,20
ST   D13S317: 11
ST   D16S539: 10,13
ST   D18S51: 12,16
ST   D19S433: 13,14
ST   D1S1656: 15,16.3
ST   D21S11: 32.2,33.2
ST   D22S1045: 17
ST   D2S1338: 20,24
ST   D2S441: 14
ST   D3S1358: 14,16
ST   D5S818: 11
ST   D7S820: 10 (Cosmic-CLP=1479987; Millipore=SCC186; PubMed=22710073; PubMed=25877200; Technion Genomics Center)
ST   D7S820: 10,11 (PubMed=30485824)
ST   D8S1179: 12,14 (Millipore=SCC186)
ST   D8S1179: 14 (PubMed=22710073; PubMed=25877200; Technion Genomics Center)
ST   FGA: 21,24
ST   Penta D: 3.2,8
ST   Penta E: 8
ST   TH01: 6,9.3
ST   TPOX: 6,8
ST   vWA: 17,19 (Millipore=SCC186)
ST   vWA: 19 (Cosmic-CLP=1479987; PubMed=22710073; PubMed=25877200; PubMed=30485824; Technion Genomics Center)
DI   NCIt; C7700; Ovarian adenocarcinoma
DI   ORDO; Orphanet_213504; Adenocarcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 41
CH   CVCL_X010 ! NOSE-06
CH   CVCL_X011 ! NOSE-07
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
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RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
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RL   Cell 166:740-754(2016).
//
RX   PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H;
RA   Rauh-Adelmann, Christine
RA   Lau, Kin-Mang
RA   Sabeti, Nari
RA   Long, John P.
RA   Mok, Samuel C.
RA   Ho, Shuk-Mei
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RT   12 deletion variant in malignant human ovarian, prostate, and breast
RT   cancer cell lines.";
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//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=10318951; DOI=10.1073/pnas.96.10.5722; PMCID=PMC21927;
RA   Lau, Kin-Mang
RA   Mok, Samuel C.
RA   Ho, Shuk-Mei
RT   "Expression of human estrogen receptor-alpha and -beta, progesterone
RT   receptor, and androgen receptor mRNA in normal and malignant ovarian
RT   epithelial cells.";
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//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=16380993; DOI=10.1002/ijc.21671;
RA   Huang, Kuan-Chun
RA   Park, Dong Choon
RA   Ng, Shu-Kay
RA   Lee, Ji Young
RA   Ni, Xiao-Yan
RA   Ng, Wing-Chung
RA   Bandera, Christina Ann
RA   Welch, William R.
RA   Berkowitz, Ross Stuart
RA   Mok, Samuel C.
RA   Ng, Shu-Wing
RT   "Selenium binding protein 1 in ovarian cancer.";
RL   Int. J. Cancer 118:2433-2440(2006).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=7836420; DOI=10.1074/jbc.270.3.999;
RA   Young, Timothy N.
RA   Pizzo, Salvatore Vincent
RA   Stack, Mary Sharon
RT   "A plasma membrane-associated component of ovarian adenocarcinoma
RT   cells enhances the catalytic efficiency of matrix metalloproteinase-2.";
RL   J. Biol. Chem. 270:999-1002(1995).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023;
RA   Stordal, Britta
RA   Timms, Kirsten
RA   Farrelly, Angela
RA   Gallagher, Danielle
RA   Busschots, Steven
RA   Renaud, Mickael
RA   Thery, Julien
RA   Williams, Deborah
RA   Potter, Jennifer
RA   Tran, Thanh
RA   Korpanty, Greg
RA   Cremona, Mattia
RA   Carey, Mark S.
RA   Li, Jie
RA   Li, Yang
RA   Aslan, Ozlem
RA   O'Leary, John J.
RA   Mills, Gordon B.
RA   Hennessy, Bryan T.
RT   "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one
RT   functionally deleterious BRCA1 mutation.";
RL   Mol. Oncol. 7:567-579(2013).
//
RX   PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945;
RA   Papp, Eniko
RA   Hallberg, Dorothy
RA   Konecny, Gottfried E.
RA   Bruhm, Daniel C.
RA   Adleff, Vilmos
RA   Noe, Michael
RA   Kagiampakis, Ioannis
RA   Palsgrove, Doreen
RA   Conklin, Dylan
RA   Kinose, Yasuto
RA   White, James R.
RA   Press, Michael Frederick
RA   Drapkin, Ronny I.
RA   Easwaran, Hariharan
RA   Baylin, Stephen Bruce
RA   Slamon, Dennis Joseph
RA   Velculescu, Victor E.
RA   Scharpf, Robert B.
RT   "Integrated genomic, epigenomic, and expression analyses of ovarian
RT   cancer cell lines.";
RL   Cell Rep. 25:2617-2633(2018).
//
RX   PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461;
RA   Coscia, Fabian
RA   Watters, Karen M.
RA   Curtis, Marion
RA   Eckert, Mark A.
RA   Chiang, Chun-Yi
RA   Tyanova, Stefka
RA   Montag, Anthony
RA   Lastra, Ricardo R.
RA   Lengyel, Ernst Robert
RA   Mann, Matthias
RT   "Integrative proteomic profiling of ovarian cancer cell lines reveals
RT   precursor cell associated proteins and functional status.";
RL   Nat. Commun. 7:12645.1-12645.14(2016).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=1536252; DOI=10.1016/0002-9378(92)91697-9;
RA   Berchuck, Andrew
RA   Rodriguez, Gus
RA   Olt, George
RA   Whitaker, Regina
RA   Boente, Matthew P.
RA   Arrick, Bradley A.
RA   Clarke-Pearson, Daniel Lyle
RA   Bast, Robert Clinton Jr.
RT   "Regulation of growth of normal ovarian epithelial cells and ovarian
RT   cancer cell lines by transforming growth factor-beta.";
RL   Am. J. Obstet. Gynecol. 166:676-684(1992).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//