ID   QGY-7703
AC   CVCL_6715
SY   QGY7703; QGY
DR   BTO; BTO_0005721
DR   ChEMBL-Cells; CHEMBL4295478
DR   ChEMBL-Targets; CHEMBL4296490
DR   GEO; GSM936775
DR   GEO; GSM1374839
DR   PubChem_Cell_line; CVCL_6715
DR   Wikidata; Q54948825
RX   CelloPub=CLPUB00100;
RX   PubMed=6280941;
RX   PubMed=10567879;
RX   PubMed=19139770;
RX   PubMed=23505090;
RX   PubMed=28807831;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=28807831). Originally thought to originate from a 35 year old female patient with hepatocellular carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00552.
CC   Population: African American.
CC   Doubling time: 20.5 hours (PubMed=6280941); 36.3 +- 1.5 hours (PubMed=19139770).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3131C0001000700043). It was the sole source for the STR profile of this entry.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): CCRID
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 12
ST   D8S1179: 12
ST   FGA: 18,21
ST   TH01: 7
ST   TPOX: 12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
CH   CVCL_M360 ! QGY/cDDP
//
RX   PubMed=10567879; DOI=10.1159/000030097;
RA   Luo, Dan
RA   Cheng, Samuel Chak-Sum
RA   Xie, Hong
RA   Xie, Yong
RT   "Chemosensitivity of human hepatocellular carcinoma cell line QGY-7703
RT   is related to bcl-2 protein levels.";
RL   Tumor Biol. 20:331-340(1999).
//
RX   PubMed=6280941;
RA   Wang, Jin-Bing
RA   Zhu, De-Hou
RA   Ye, Xiu-Zhen
RA   Chen, Rui-Ming
RT   "Establishment and some characteristics of a hepatoma cell line
RT   (QGY-7703).";
RL   Zhonghua Zhong Liu Za Zhi 3:241-244(1981).
//
RX   CelloPub=CLPUB00100;
RA   Zhu, De-Hou
RA   Wang, Jin-Bing
RT   "Establishment and comparison of non-malignant liver cell QSG-7701 and
RT   liver cancer cells.";
RL   Zhong Liu Fang Zhi Yan Jiu 5:7-9(1979).
//
RX   PubMed=23505090; DOI=10.1002/hep.26402;
RA   Wang, Kai
RA   Lim, Ho Yeong
RA   Shi, Stephanie
RA   Lee, Jeeyun
RA   Deng, Shi-Bing
RA   Xie, Tao
RA   Zhu, Zhou
RA   Wang, Yu-Li
RA   Pocalyko, David
RA   Yang, Wei Jennifer
RA   Rejto, Paul A.
RA   Mao, Mao
RA   Park, Cheol-Keun
RA   Xu, Jiang-Chun
RT   "Genomic landscape of copy number aberrations enables the
RT   identification of oncogenic drivers in hepatocellular carcinoma.";
RL   Hepatology 58:706-717(2013).
//
RX   PubMed=19139770;
RA   Yang, Jun-Xia
RA   Luo, Ying
RA   Qiu, Hong-Mei
RA   Tang, Wei-Xue
RT   "Characterization and resistance mechanisms of cisplatin-resistant
RT   human hepatocellular carcinoma cell line.";
RL   Saudi Med. J. 30:35-40(2009).
//
RX   PubMed=28807831; DOI=10.1016/j.jhep.2017.08.002;
RA   Rebouissou, Sandra
RA   Zucman-Rossi, Jessica
RA   Moreau, Richard
RA   Qiu, Zhi-Xin
RA   Hui, Li-Jian
RT   "Note of caution: contaminations of hepatocellular cell lines.";
RL   J. Hepatol. 67:896-897(2017).
//