ID   P116.cl39
AC   CVCL_6430
SY   P116.c39
DR   CLO; CLO_0008293
DR   ATCC; CRL-2677
DR   BioSample; SAMN03471762
DR   cancercelllines; CVCL_6430
DR   LINCS_LDP; LCL-1032
DR   Wikidata; Q54937223
RX   PubMed=9488454;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 12858; ZAP70 (with a N-terminal Myc tag).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC=CRL-2677
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,12
ST   D16S539: 11
ST   D18S51: 13,20
ST   D19S433: 14,15.2
ST   D21S11: 32.2,33.2,34.2
ST   D2S1338: 18,23
ST   D3S1358: 15,17
ST   D5S818: 9
ST   D7S820: 8,11.3
ST   D8S1179: 12,13,14
ST   FGA: 20,21
ST   Penta D: 11,12
ST   Penta E: 10,12
ST   TH01: 6,9.3
ST   TPOX: 8,10
ST   vWA: 19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6429 ! P116
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 27
//
RX   PubMed=9488454; DOI=10.1128/mcb.18.3.1388;
RA   Williams B.L., Schreiber K.L., Zhang W.-G., Wange R.L., Samelson L.E.,
RA   Leibson P.J., Abraham R.T.;
RT   "Genetic evidence for differential coupling of Syk family kinases to
RT   the T-cell receptor: reconstitution studies in a ZAP-70-deficient
RT   Jurkat T-cell line.";
RL   Mol. Cell. Biol. 18:1388-1399(1998).
//