ID   K2 [Human thyroid carcinoma]
AC   CVCL_6308
DR   BioSample; SAMN03151644
DR   cancercelllines; CVCL_6308
DR   Cosmic; 928834
DR   Cosmic; 1162846
DR   Cosmic; 1789443
DR   Wikidata; Q54899267
RX   PubMed=9054892;
RX   PubMed=10646882;
RX   PubMed=18713817;
RX   PubMed=20143388;
RX   PubMed=21868764;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a GLAG-66 derivative (PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00219.
CC   Population: Caucasian; Italian.
CC   Doubling time: 23 hours (PubMed=9054892).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
CC   Derived from site: Metastatic; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=18713817; PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,14
ST   D16S539: 11,12
ST   D18S51: 18
ST   D21S11: 30,31.2
ST   D3S1358: 18
ST   D5S818: 10,11
ST   D7S820: 11
ST   D8S1179: 15
ST   FGA: 21,24
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C4035; Thyroid gland papillary carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9918 ! GLAG-66
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 30
//
RX   PubMed=9054892; DOI=10.1016/S0360-3016(96)00449-X;
RA   Challeton de Vathaire, Cecile
RA   Branea, Felicia
RA   Schlumberger, Martin
RA   Gaillard, Nadine
RA   de Vathaire, Florent
RA   Badie, Christophe
RA   Antonini, Patrick
RA   Parmentier, Claude
RT   "Characterization and radiosensitivity at high or low dose rate of
RT   four cell lines derived from human thyroid tumors.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 37:163-169(1997).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569;
RA   Schweppe, Rebecca E.
RA   Klopper, Joshua Paul
RA   Korch, Christopher T.
RA   Pugazhenthi, Umarani
RA   Benezra, Miriam
RA   Knauf, Jeffrey A.
RA   Fagin, James Alexander
RA   Marlow, Laura A.
RA   Copland, John Alton 3rd
RA   Smallridge, Robert Christian
RA   Haugen, Bryan R.
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=10646882; DOI=10.1054/bjoc.1999.0920; PMCID=PMC2363282;
RA   Bounacer, Ali
RA   Schlumberger, Martin
RA   Wicker, Rene
RA   du Villard, Jean-Antoine
RA   Caillou, Bernard
RA   Sarasin, Alain
RA   Suarez, Horacio Guillermo
RT   "Search for NTRK1 proto-oncogene rearrangements in human thyroid
RT   tumours originated after therapeutic radiation.";
RL   Br. J. Cancer 82:308-314(2000).
//