ID   TTA-1
AC   CVCL_6297
SY   TTA1; TTA-I
DR   BTO; BTO_0004965
DR   cancercelllines; CVCL_6297
DR   CCRID; 3101HUMSCSP554
DR   CGH-DB; 46-1
DR   CLS; 305138
DR   Cosmic; 1152125
DR   Cosmic; 1239984
DR   Cosmic; 2054119
DR   RCB; RCB5467
DR   Wikidata; Q54973227
RX   Patent=US8029793;
RX   PubMed=8121182;
RX   PubMed=8176927;
RX   PubMed=9177455;
RX   PubMed=15613457;
RX   PubMed=16924234;
RX   PubMed=18713817;
RX   PubMed=23833040;
RX   PubMed=30737244;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Japanese National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology; FERM BP-7523.
CC   Population: Japanese.
CC   Doubling time: 28.8 hours (PubMed=8121182).
CC   Sequence variation: Mutation; HGNC; HGNC:7883; NOTCH3; Simple; p.Gly289fs (c.866delG); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg158Leu (c.473G>T); ClinVar=VCV000528248; Zygosity=Homozygous (PubMed=30737244).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=18713817; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 9,10
ST   D18S51: 15
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 11,12
ST   D8S1179: 13,15
ST   FGA: 23
ST   TH01: 6
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
//
RX   Patent=US8029793;
RA   Yoshida, Akira
RA   Yanoma, Shunsuke
RA   Hirose, Fumikazu
RT   "Methods for inhibiting cell proliferation.";
RL   Patent number US8029793, 04-Oct-2011.
//
RX   PubMed=15613457; DOI=10.1677/erc.1.00818;
RA   Onda, Masahiko
RA   Emi, Mitsuru
RA   Yoshida, Akira
RA   Miyamoto, Shizuyo
RA   Akaishi, Junko
RA   Asaka, Shin-ichi
RA   Mizutani, Kosuke
RA   Shimizu, Kazuo
RA   Nagahama, Munehiko
RA   Ito, Kouichi
RA   Tanaka, Toshihiro
RA   Tsunoda, Tatsuhiko
RT   "Comprehensive gene expression profiling of anaplastic thyroid cancers
RT   with cDNA microarray of 25 344 genes.";
RL   Endocr. Relat. Cancer 11:843-854(2004).
//
RX   PubMed=8121182; DOI=10.1002/jso.2930550209;
RA   Yoshida, Akira
RA   Asaga, Tarou
RA   Masuzawa, Chihiro
RA   Kawahara, Satoru
RA   Yanoma, Shunsuke
RA   Harada, Masaoki
RA   Okamoto, Takasi
RT   "Production of cytokines by thyroid carcinoma cell lines.";
RL   J. Surg. Oncol. 55:104-107(1994).
//
RX   PubMed=8176927; DOI=10.1002/jso.2930550308;
RA   Yoshida, Akira
RA   Asaga, Tarou
RA   Masuzawa, Chihiro
RA   Kawahara, Satoru
RT   "Alteration of tumorigenicity in undifferentiated thyroid carcinoma
RT   cells by introduction of normal chromosome 11.";
RL   J. Surg. Oncol. 55:170-174(1994).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569;
RA   Schweppe, Rebecca E.
RA   Klopper, Joshua Paul
RA   Korch, Christopher T.
RA   Pugazhenthi, Umarani
RA   Benezra, Miriam
RA   Knauf, Jeffrey A.
RA   Fagin, James Alexander
RA   Marlow, Laura A.
RA   Copland, John Alton 3rd
RA   Smallridge, Robert Christian
RA   Haugen, Bryan R.
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971;
RA   Landa, Inigo
RA   Ganly, Ian
RA   Chan, Timothy A.
RA   Mitsutake, Norisato
RA   Matsuse, Michiko
RA   Ibrahimpasic, Tihana
RA   Ghossein, Ronald A.
RA   Fagin, James Alexander
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//
RX   PubMed=16924234; DOI=10.1038/sj.onc.1209899;
RA   Yu, Wei
RA   Imoto, Issei
RA   Inoue, Jun
RA   Onda, Masahiko
RA   Emi, Mitsuru
RA   Inazawa, Johji
RT   "A novel amplification target, DUSP26, promotes anaplastic thyroid
RT   cancer cell growth by inhibiting p38 MAPK activity.";
RL   Oncogene 26:1178-1187(2007).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa, Inigo
RA   Pozdeyev, Nikita
RA   Korch, Christopher T.
RA   Marlow, Laura A.
RA   Smallridge, Robert Christian
RA   Copland, John Alton 3rd
RA   Henderson, Ying C.
RA   Lai, Stephen Y.
RA   Clayman, Gary L.
RA   Onoda, Naoyoshi
RA   Tan, Aik-Choon
RA   Garcia-Rendueles, Maria E.R.
RA   Knauf, Jeffrey A.
RA   Haugen, Bryan R.
RA   Fagin, James Alexander
RA   Schweppe, Rebecca E.
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   PubMed=9177455; DOI=10.1016/S0304-3835(97)04742-3;
RA   Satake, Shoji
RA   Sugawara, Isamu
RA   Watanabe, Masatoshi
RA   Takami, Hiroshi
RT   "Lack of a point mutation of human DNA topoisomerase II in
RT   multidrug-resistant anaplastic thyroid carcinoma cell lines.";
RL   Cancer Lett. 116:33-39(1997).
//