ID   HTh74
AC   CVCL_6288
SY   Hth74; HTH74; HTh 74; HTh-74; Uhth-74; U-hth74
DR   BTO; BTO_0005147
DR   Cosmic; 889490
DR   Cosmic; 1068623
DR   Cosmic; 1084284
DR   Cosmic; 1132594
DR   Cosmic; 1152119
DR   Cosmic; 1239982
DR   Cosmic; 1280050
DR   Cosmic; 1507377
DR   Cosmic; 1533554
DR   Cosmic; 1536130
DR   Cosmic; 1889009
DR   Cosmic; 2036690
DR   Cosmic; 2050368
DR   Cosmic; 2054102
DR   Cosmic; 2319855
DR   Cosmic; 2791086
DR   IARC_TP53; 21622
DR   IARC_TP53; 25014
DR   Wikidata; Q54896656
RX   PubMed=1655394;
RX   PubMed=1726925;
RX   PubMed=14522906;
RX   PubMed=17465858;
RX   PubMed=17725429;
RX   PubMed=18713817;
RX   PubMed=19087340;
RX   PubMed=23833040;
RX   PubMed=25365311;
RX   PubMed=30737244;
CC   Characteristics: Established from a tumor implanted into a nude mice (PubMed=1655394).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Leu732fs (c.2195_2202delTGCCCAAC); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=30737244).
CC   Omics: Transcriptomics; Microarray.
CC   Misspelling: Hth47; Cosmic=889490.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): PubMed=17465858; PubMed=18713817; PubMed=25365311; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10,12 (PubMed=30737244)
ST   CSF1PO: 11,12 (PubMed=25365311)
ST   D13S317: 12,13
ST   D16S539: 9 (PubMed=25365311)
ST   D16S539: 11 (PubMed=30737244)
ST   D18S51: 14
ST   D21S11: 31,32 (PubMed=17465858; PubMed=30737244)
ST   D21S11: 32 (PubMed=18713817)
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 8,9 (PubMed=17465858; PubMed=18713817; PubMed=30737244)
ST   D7S820: 9 (PubMed=25365311)
ST   D8S1179: 13,15 (PubMed=17465858; PubMed=30737244)
ST   D8S1179: 13,15,16 (PubMed=18713817)
ST   FGA: 25
ST   TH01: 8 (PubMed=25365311)
ST   TH01: 8,9 (PubMed=30737244)
ST   TPOX: 8,10 (PubMed=25365311)
ST   TPOX: 11 (PubMed=30737244)
ST   vWA: 16,17 (PubMed=25365311)
ST   vWA: 17,19 (PubMed=17465858; PubMed=18713817; PubMed=30737244)
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   73Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 27
//
RX   PubMed=1655394; DOI=10.1210/endo-129-4-2187;
RA   Heldin N.-E., Cvejic D., Smeds S., Westermark B.;
RT   "Coexpression of functionally active receptors for thyrotropin and
RT   platelet-derived growth factor in human thyroid carcinoma cells.";
RL   Endocrinology 129:2187-2193(1991).
//
RX   PubMed=1726925;
RA   Gerber H., Peter H.-J., Asmis L., Studer H.;
RT   "Thyroid cell lines in research on goitrogenesis.";
RL   Thyroidology 3:115-118(1991).
//
RX   PubMed=14522906;
RA   Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R.,
RA   Vigneri P.;
RT   "p73 tumor-suppressor activity is impaired in human thyroid cancer.";
RL   Cancer Res. 63:5829-5837(2003).
//
RX   PubMed=17465858; DOI=10.1089/thy.2006.0246;
RA   Lee J.-J., Foukakis T., Hashemi J., Grimelius L., Heldin N.-E.,
RA   Wallin G., Rudduck C., Lui W.-O., Hoog A., Larsson C.;
RT   "Molecular cytogenetic profiles of novel and established human
RT   anaplastic thyroid carcinoma models.";
RL   Thyroid 17:289-301(2007).
//
RX   PubMed=17725429; DOI=10.1089/thy.2007.0097;
RA   Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V.,
RA   Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R.,
RA   Trovisco V., Cirnes L., Alves C., Velho S., Soares P.,
RA   Sobrinho-Simoes M.;
RT   "Molecular and genotypic characterization of human thyroid follicular
RT   cell carcinoma-derived cell lines.";
RL   Thyroid 17:707-715(2007).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569;
RA   Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M.,
RA   Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C.,
RA   Haugen B.R.;
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//
RX   PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892;
RA   Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.;
RT   "Conventional and molecular cytogenetics of human non-medullary
RT   thyroid carcinoma: characterization of eight cell line models and
RT   review of the literature on clinical samples.";
RL   BMC Cancer 8:371.1-371.11(2008).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971;
RA   Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M.,
RA   Ibrahimpasic T., Ghossein R.A., Fagin J.A.;
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//
RX   PubMed=25365311; DOI=10.1210/jc.2014-2359; PMCID=PMC4318896;
RA   Garg M., Okamoto R., Nagata Y., Kanojia D., Venkatesan S., Anand M.T.,
RA   Braunstein G.D., Said J.W., Doan N.B., Ho Q., Akagi T., Gery S.,
RA   Liu L.-Z., Tan K.-T., Chang W.J., Yang H.H., Ogawa S., Koeffler H.P.;
RT   "Establishment and characterization of novel human primary and
RT   metastatic anaplastic thyroid cancer cell lines and their genomic
RT   evolution over a year as a primagraft.";
RL   J. Clin. Endocrinol. Metab. 100:725-735(2015).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//