ID   BHP 15-3
AC   CVCL_6280
SY   BHP15-3; BHP-15
DR   cancercelllines; CVCL_6280
DR   Wikidata; Q54796492
RX   PubMed=8675585;
RX   PubMed=28940260;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a thyroid gland papillary carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00555.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
ST   Source(s): PubMed=28940260
ST   Amelogenin: X
ST   D13S317: 12
ST   D18S51: 13,17
ST   D21S11: 30
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 13
ST   FGA: 21
ST   vWA: 16,18
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1395 ! M14
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
//
RX   PubMed=28940260; DOI=10.1002/ijc.31067; PMCID=PMC5762610;
RA   Korch, Christopher T.
RA   Hall, Erin M.
RA   Dirks, Wilhelm Gerhard
RA   Ewing, Margaret
RA   Faries, Mark
RA   Varella-Garcia, Marileila
RA   Robinson, Steven
RA   Storts, Douglas R.
RA   Turner, Jacqueline A.
RA   Wang, Ying
RA   Burnett, Edward C.
RA   Healy, Lyn E.
RA   Kniss, Douglas A.
RA   Neve, Richard M.
RA   Nims, Raymond Whiting
RA   Reid, Yvonne A.
RA   Robinson, William A.
RA   Capes-Davis, Amanda
RT   "Authentication of M14 melanoma cell line proves misidentification of
RT   MDA-MB-435 breast cancer cell line.";
RL   Int. J. Cancer 142:561-572(2018).
//
RX   PubMed=8675585; DOI=10.1210/jcem.81.7.8675585;
RA   Ohta, Kazuyasu
RA   Pang, Xuan-Ping
RA   Berg, Loretta
RA   Hershman, Jerome Marshall
RT   "Antitumor actions of cytokines on new human papillary thyroid
RT   carcinoma cell lines.";
RL   J. Clin. Endocrinol. Metab. 81:2607-2612(1996).
//