ID   SK-RC-48
AC   CVCL_6195
SY   SK RC 48; SKRC48
DR   Cosmic; 972919
DR   Wikidata; Q54954595
RX   PubMed=2386958;
RX   PubMed=7915601;
WW   Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-rc-p-primary-human-renal-cell-carcinoma-rcc-cell-line-collection
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; p.Leu135Tyrfs*24 (c.404delT); Zygosity=Unspecified (PubMed=7915601).
CC   Miscellaneous: STR profile and age/sex of donor from MSKCC antibody and bioresource core facility.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 13
ST   D16S539: 11
ST   D18S51: 14
ST   D19S433: 12,16
ST   D21S11: 28,30
ST   D2S1338: 20
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 9,12
ST   D8S1179: 11,13
ST   FGA: 20
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   73Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
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RX   PubMed=2386958;
RA   Ebert T., Bander N.H., Finstad C.L., Ramsawak R.D., Old L.J.;
RT   "Establishment and characterization of human renal cancer and normal
RT   kidney cell lines.";
RL   Cancer Res. 50:5531-5536(1990).
//
RX   PubMed=7915601; DOI=10.1038/ng0594-85;
RA   Gnarra J.R., Tory K., Weng Y.-K., Schmidt L.S., Wei M.H., Li H., Latif F.,
RA   Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.-S.R., Florence C.,
RA   Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H.,
RA   Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B.,
RA   Linehan W.M.;
RT   "Mutations of the VHL tumour suppressor gene in renal carcinoma.";
RL   Nat. Genet. 7:85-90(1994).
//