ID   Y1-Kin-2
AC   CVCL_5G21
SY   Kin-2; Kin 2
DR   Wikidata; Q54995186
RX   PubMed=221910;
RX   PubMed=6270152;
RX   PubMed=8388994;
RX   PubMed=15541570;
CC   Selected for resistance to: ChEBI; CHEBI_64211; 8-bromo-3',5'-cyclic AMP (8-bromoadenosine 3',5'-cyclic monophosphate; 8-Br-cAMP).
CC   Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
CC   Breed/subspecies: LAF1.
DI   NCIt; C22992; Mouse adrenal cortical carcinoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_W154 ! Y1-BS1
SX   Male
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 19-12-24; Version: 7
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RX   PubMed=221910; DOI=10.1073/pnas.76.4.1896; PMCID=PMC383499;
RA   Rae P.A., Gutmann N.S., Tsao J., Schimmer B.P.;
RT   "Mutations in cyclic AMP-dependent protein kinase and corticotropin
RT   (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:1896-1900(1979).
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RX   PubMed=6270152; DOI=10.1016/S0021-9258(19)68600-X;
RA   Watt V.M., Schimmer B.P.;
RT   "Association of a 68,000-dalton protein with adrenocorticotropin-sensitive
RT   adenylate cyclase activity in Y1 adrenocortical tumor cells.";
RL   J. Biol. Chem. 256:11365-11371(1981).
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RX   PubMed=8388994; DOI=10.1210/mend.7.4.8388994;
RA   Olson M.F., Krolczyk A.J., Gorman K.B., Steinberg R.A., Schimmer B.P.;
RT   "Molecular basis for the 3',5'-cyclic adenosine monophosphate
RT   resistance of Kin mutant Y1 adrenocortical tumor cells.";
RL   Mol. Endocrinol. 7:477-487(1993).
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RX   PubMed=15541570; DOI=10.1016/j.mce.2003.12.020;
RA   Rainey W.E., Saner K., Schimmer B.P.;
RT   "Adrenocortical cell lines.";
RL   Mol. Cell. Endocrinol. 228:23-38(2004).
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