ID   CHO-DXB11 F435
AC   CVCL_5A31
SY   F435
DR   Wikidata; Q54833139
RX   PubMed=19906157;
RX   PubMed=25887056;
CC   Sequence variation: Gene deletion; UniProtKB; Q2MH30; Dhfr; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; Q2MH30; Dhfr; Simple; p.Thr137Arg (c.410G>C); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3546; F8 (Note=Construct called N8 with 20-769 and 1657-2351).
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:94890; Dhfr.
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Transformant: NCIt; C44386; Gamma radiation.
CC   Omics: Genomics; Whole genome sequencing.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_1977 ! CHO-DXB11
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 14-12-15; Last updated: 10-04-25; Version: 11
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RX   PubMed=19906157; DOI=10.1111/j.1365-2516.2009.02135.x;
RA   Thim L., Vandahl B.S., Karlsson J., Klausen N.K., Pedersen J.,
RA   Krogh T.N., Kjalke M., Petersen J.M., Johnsen L.B., Bolt G.,
RA   Norby P.L., Steenstrup T.D.;
RT   "Purification and characterization of a new recombinant factor VIII
RT   (N8).";
RL   Haemophilia 16:349-359(2010).
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RX   PubMed=25887056; DOI=10.1186/s12864-015-1391-x; PMCID=PMC4359788;
RA   Kaas C.S., Kristensen C., Betenbaugh M.J., Andersen M.R.;
RT   "Sequencing the CHO DXB11 genome reveals regional variations in
RT   genomic stability and haploidy.";
RL   BMC Genomics 16:160.1-160.9(2015).
//