ID   JHU-022
AC   CVCL_5991
SY   JHU-022-SCC; JHU022; JHU-O22; JHU-22; HNSCC 022; O22; 022; Johns Hopkins University-022
DR   BTO; BTO_0003887
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2722
DR   BioGRID_ORCS_Cell_line; 907
DR   cancercelllines; CVCL_5991
DR   Cell_Model_Passport; SIDM00127
DR   Cosmic; 1122671
DR   Cosmic; 1530748
DR   Cosmic; 2131848
DR   Cosmic-CLP; 1240162
DR   DepMap; ACH-002250
DR   EGA; EGAS00001000978
DR   GDSC; 1240162
DR   GEO; GSM1669959
DR   PharmacoDB; JHU022_695_2019
DR   PRIDE; PXD002132
DR   PRIDE; PXD030304
DR   Wikidata; Q54898674
RX   PubMed=12925955;
RX   PubMed=12963126;
RX   PubMed=17848307;
RX   PubMed=21868764;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Genome ancestry: African=0.81%; Native American=0.12%; East Asian, North=1.81%; East Asian, South=0%; South Asian=0%; European, North=63.12%; European, South=34.14% (PubMed=30894373).
CC   Misspelling: JUH022; Cosmic=2131848.
CC   Discontinued: ATCC; CRL-2722; true.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
ST   Source(s): ATCC=CRL-2722; Cosmic-CLP=1240162; PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 12
ST   D5S818: 12,13
ST   D7S820: 9,10
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 14,16
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
CH   CVCL_5987 ! JHU-012
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082;
RA   Yarbrough, Wendell Gray
RA   Whigham, Amy
RA   Brown, Brandee
RA   Roach, Michael
RA   Slebos, Robbert J.C.
RT   "Phosphoinositide kinase-3 status associated with presence or absence
RT   of human papillomavirus in head and neck squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=12925955; DOI=10.1002/ijc.11341;
RA   Minhas, Khalid M.
RA   Singh, Bhuvanesh
RA   Jiang, Wei-Wen
RA   Sidransky, David
RA   Califano, Joseph A. 3rd
RT   "Spindle assembly checkpoint defects and chromosomal instability in
RT   head and neck squamous cell carcinoma.";
RL   Int. J. Cancer 107:46-52(2003).
//
RX   PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6;
RA   Hoque, Mohammad Obaidul
RA   Begum, Shahnaz
RA   Sommer, Matthias
RA   Lee, Taekyeol
RA   Trink, Barry
RA   Ratovitski, Edward
RA   Sidransky, David
RT   "PUMA in head and neck cancer.";
RL   Cancer Lett. 199:75-81(2003).
//