ID   UM-SCV-3
AC   CVCL_5975
SY   UMSCV-3; University of Michigan-Squamous cell Carcinoma of the Vulva-3
DR   cancercelllines; CVCL_5975
DR   IARC_TP53; 6927
DR   Wikidata; Q54990962
RX   PubMed=1777413;
RX   PubMed=1958593;
RX   PubMed=7503188;
RX   PubMed=7599042;
RX   PubMed=9887230;
RX   PubMed=15047230;
CC   Doubling time: 76 hours (PubMed=15047230).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=7503188; PubMed=9887230).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser314Ser (c.942C>T); dbSNP=rs765930028; Zygosity=Unspecified (PubMed=7503188; PubMed=9887230).
CC   Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
DI   NCIt; C4052; Vulvar squamous cell carcinoma
DI   ORDO; Orphanet_494448; Vulvar squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 21
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RX   PubMed=1777413; DOI=10.1002/gcc.2870030604;
RA   Worsham M.J., Van Dyke D.L., Grenman S.E., Grenman R., Hopkins M.P.,
RA   Roberts J.A., Gasser K.M., Schwartz D.R., Carey T.E.;
RT   "Consistent chromosome abnormalities in squamous cell carcinoma of the
RT   vulva.";
RL   Genes Chromosomes Cancer 3:420-432(1991).
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RX   PubMed=1958593; DOI=10.1002/gcc.2870030406;
RA   Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J.,
RA   Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S.,
RA   Carey T.E.;
RT   "11p deletions and breakpoints in squamous cell carcinoma: association
RT   with altered reactivity with the UM-E7 antibody.";
RL   Genes Chromosomes Cancer 3:272-282(1991).
//
RX   PubMed=7503188; DOI=10.1016/0002-9378(95)90636-3;
RA   Hietanen S.H., Kurvinen K., Syrjanen K.J., Grenman S.E., Carey T.E.,
RA   McClatchey K.D., Syrjanen S.M.;
RT   "Mutation of tumor suppressor gene p53 is frequently found in vulvar
RT   carcinoma cells.";
RL   Am. J. Obstet. Gynecol. 173:1477-1482(1995).
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RX   PubMed=7599042; DOI=10.1038/bjc.1995.289; PMCID=PMC2034151;
RA   Hietanen S.H., Grenman S.E., Syrjanen K.J., Lappalainen K., Kauppinen J.,
RA   Carey T.E., Syrjanen S.M.;
RT   "Human papillomavirus in vulvar and vaginal carcinoma cell lines.";
RL   Br. J. Cancer 72:134-139(1995).
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RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen V., Grenman S.E., Kurvinen K., Hietanen S.H., Raitanen M.,
RA   Syrjanen S.M.;
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
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RX   PubMed=15047230; DOI=10.1016/j.ygyno.2003.12.033;
RA   Raitanen M., Worsham M.J., Lakkala T., Carey T.E., Van Dyke D.L.,
RA   Grenman R., Klemi P., Rantanen V., Isola J.J., Grenman S.E.;
RT   "Characterization of 10 vulvar carcinoma cell lines by karyotyping,
RT   comparative genomic hybridization and flow cytometry.";
RL   Gynecol. Oncol. 93:155-163(2004).
//