ID   TUHR4TKB
AC   CVCL_5957
SY   TUHR-4TKB; 4TUHR; 4T
DR   BTO; BTO:0003729
DR   CLO; CLO_0050898
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 353
DR   BioSample; SAMN03472178
DR   BioSample; SAMN10987695
DR   cancercelllines; CVCL_5957
DR   Cell_Model_Passport; SIDM01432
DR   DepMap; ACH-000495
DR   GEO; GSM887717
DR   GEO; GSM888810
DR   IARC_TP53; 30184
DR   LiGeA; CCLE_767
DR   PharmacoDB; TUHR4TKB_1612_2019
DR   Progenetix; CVCL_5957
DR   RCB; RCB1198
DR   Wikidata; Q54973374
RX   PubMed=9914789;
RX   PubMed=10929426;
RX   PubMed=14534724;
RX   PubMed=15604581;
RX   PubMed=22185343;
RX   PubMed=22460905;
RX   PubMed=26589293;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   HLA typing: A*02:06,02:06; B*15:18,15:18; C*07:04,07:04; DQA1*03:02,03:02; DQB1*03:02,03:02; DRB1*08:02,08:02 (PubMed=26589293).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=3.62%; Native American=0%; East Asian, North=85.09%; East Asian, South=5.8%; South Asian=0%; European, North=0%; European, South=5.48% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): RCB=RCB1198
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,11
ST   D16S539: 11,12
ST   D5S818: 10,12
ST   D7S820: 12,13
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 15,17
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 25
//
RX   PubMed=9914789; DOI=10.1111/j.1349-7006.1998.tb00515.x; PMCID=PMC5921718;
RA   Liu S.-Q., Kawai K., Shiraiwa H., Hayashi H., Akaza H., Hashizaki K.,
RA   Shiba R., Saijo K., Ohno T.;
RT   "High rate of induction of human autologous cytotoxic T lymphocytes
RT   against renal carcinoma cells cultured with an interleukin
RT   cocktail.";
RL   Jpn. J. Cancer Res. 89:1195-1201(1998).
//
RX   PubMed=10929426; DOI=10.1007/s002400000103;
RA   Shintaku I., Kawagoe N., Yutani S., Hoshi S., Orikasa S.,
RA   Yoshizumi O., Itoh K.;
RT   "Expression of the SART1 tumor rejection antigen in renal cell
RT   carcinoma.";
RL   Urol. Res. 28:178-184(2000).
//
RX   PubMed=14534724; DOI=10.3892/or.10.6.1947;
RA   Ikemoto S., Narita K., Yoshida N., Wada S., Kishimoto T., Sugimura K.,
RA   Nakatani T.;
RT   "Effects of tumor necrosis factor alpha in renal cell carcinoma.";
RL   Oncol. Rep. 10:1947-1955(2003).
//
RX   PubMed=15604581; DOI=10.1159/000081597;
RA   Ikemoto S., Sugimura K., Yoshida N., Kuratsukuri K., Wada S.,
RA   Nakatani T.;
RT   "Comparative antitumor activity of 5-fluorouracil and
RT   5'-deoxy-5-fluorouridine in combination with interferon-alpha in
RT   renal cell carcinoma cell lines.";
RL   Urol. Int. 73:348-353(2004).
//
RX   PubMed=22185343; DOI=10.1186/1471-2407-11-523; PMCID=PMC3292516;
RA   Matsuura K., Nakada C., Mashio M., Narimatsu T., Yoshimoto T.,
RA   Tanigawa M., Tsukamoto Y., Hijiya N., Takeuchi I., Nomura T., Sato F.,
RA   Mimata H., Seto M., Moriyama M.;
RT   "Downregulation of SAV1 plays a role in pathogenesis of high-grade
RT   clear cell renal cell carcinoma.";
RL   BMC Cancer 11:523.1-523.10(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135;
RA   Sinha R., Winer A.G., Chevinsky M.S., Jakubowski C., Chen Y.-B.,
RA   Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C.,
RA   Hsieh J.J.-D., Hakimi A.A.;
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165.1-15165.10(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd,
RA   Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K.,
RA   Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
RA   Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A.,
RA   Sellers W.R., Gygi S.P.;
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//