ID   11-9-1-4
AC   CVCL_5948
SY   11.9.14; BT-549Gal3
DR   BTO; BTO_0002603
DR   cancercelllines; CVCL_5948
DR   Wikidata; Q54399883
RX   PubMed=9561029;
RX   PubMed=21552935;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:2092; CLTC + HGNC; HGNC:29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Val275fs*1 (c.821delG) (p.W274fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_607del343; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>C); ClinVar=VCV000406598; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6563; LGALS3.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1092 ! BT-549
SX   Female
AG   72Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 26
//
RX   PubMed=21552935; DOI=10.3892/ijo.7.5.1079;
RA   Nangia-Makker, Pratima
RA   Thompson, Erik
RA   Hogan, Chris
RA   Ochieng, Josiah
RA   Raz, Avraham
RT   "Induction of tumorigenicity by galectin-3 in a nontumorigenic human
RT   breast-carcinoma cell-line.";
RL   Int. J. Oncol. 7:1079-1087(1995).
//
RX   PubMed=9561029;
RA   Warfield, Paula Rene
RA   Nangia-Makker, Pratima
RA   Raz, Avraham
RA   Ochieng, Josiah
RT   "Adhesion of human breast carcinoma to extracellular matrix proteins
RT   is modulated by galectin-3.";
RL   Invasion Metastasis 17:101-112(1997).
//