ID   WT-CLS1
AC   CVCL_5904
SY   CLS1
DR   CLS; 300379
DR   Cosmic; 1314022
DR   Wikidata; Q54994507
RX   DOI=10.1002/cnr2.1110;
RX   PubMed=20106868;
CC   Problematic cell line: Misclassified. Originally thought to be a Wilms tumor cell line but is a kidney rhabdoid tumor cell line (DOI=10.1002/cnr2.1110).
CC   Population: Turkish.
CC   Sequence variation: Mutation; HGNC; HGNC:11103; SMARCB1; Simple; p.Gln318Ter (c.952C>T); Zygosity=Hemizygous (DOI=10.1002/cnr2.1110).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): CLS=300379
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 9,11
ST   D16S539: 9,11
ST   D18S51: 13,15
ST   D21S11: 30,31.2
ST   D3S1358: 14,19
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 13,14
ST   FGA: 22,25
ST   Penta D: 9
ST   Penta E: 9,12
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 15,19
DI   NCIt; C8715; Rhabdoid tumor of the kidney
DI   ORDO; Orphanet_69077; Rhabdoid tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   5Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 18
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RX   PubMed=20106868; DOI=10.1093/hmg/ddq042;
RA   Royer-Pokora, Brigitte
RA   Busch, Maike Anna
RA   Beier, Manfred
RA   Duhme, Constanze
RA   de Torres, Carmen
RA   Mora, Jaume
RA   Brandt, Artur
RA   Royer, Hans-Dieter
RT   "Wilms tumor cells with WT1 mutations have characteristic features of
RT   mesenchymal stem cells and express molecular markers of paraxial
RT   mesoderm.";
RL   Hum. Mol. Genet. 19:1651-1668(2010).
//
RX   DOI=10.1002/cnr2.1110;
RA   Stroup, Emily Kunce
RA   Yeu, Yunku
RA   Budhipramono, Albert
RA   Hwang, Tae Hyun
RA   Rakheja, Dinesh
RA   Erdreich-Epstein, Anat
RA   Laetsch, Theodore Willis
RA   Amatruda, James F.
RA   Chen, Kenneth S.
RT   "WT-CLS1 is a rhabdoid tumor cell line and can be inhibited by miR-16.";
RL   Cancer Rep. 1:e1110.1-e1110.11(2018).
//