ID   KTCTL-1M
AC   CVCL_5884
SY   KTCTL1M; RCC-MF; RCCMF
DR   ArrayExpress; E-MTAB-3610
DR   cancercelllines; CVCL_5884
DR   Cell_Model_Passport; SIDM00816
DR   CLS; 300245
DR   Cosmic; 1352065
DR   Cosmic; 1751976
DR   Cosmic-CLP; 1524419
DR   DepMap; ACH-002192
DR   EGA; EGAS00001000978
DR   GDSC; 1524419
DR   GEO; GSM1670364
DR   PharmacoDB; RCCMF_1292_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54900638
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=35839778;
RX   PubMed=35902118;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:30064; PBRM1; Simple; p.Asn528Metfs*41 (c.1583del); Zygosity=Homozygous (PubMed=35902118).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=0%; East Asian, South=0.82%; South Asian=1.22%; European, North=63.61%; European, South=34.35% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): CLS=300245; Cosmic-CLP=1524419
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11,14
ST   D16S539: 13
ST   D18S51: 13,15
ST   D21S11: 29,30
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 9,10
ST   D8S1179: 10,14
ST   FGA: 20
ST   Penta D: 12,16
ST   Penta E: 7,12
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
CH   CVCL_E3WC ! RCC-MF + PBRM1 Clone 1
CH   CVCL_E3WD ! RCC-MF + PBRM1 Clone 3
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135;
RA   Sinha, Rileen
RA   Winer, Andrew G.
RA   Chevinsky, Michael Stephen
RA   Jakubowski, Christopher
RA   Chen, Ying-Bei
RA   Dong, Yi-Yu
RA   Tickoo, Satish K.
RA   Reuter, Victor E.
RA   Russo, Paul
RA   Coleman, Jonathan A.
RA   Sander, Chris
RA   Hsieh, James J.-D.
RA   Hakimi, Abraham Ari
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165.1-15165.10(2017).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35902118; DOI=10.1101/gad.349249.121; PMCID=PMC9480851;
RA   Feng, Hu-Gang
RA   Lane, Karen A.
RA   Roumeliotis, Theodoros I.
RA   Jeggo, Penelope Ann
RA   Somaiah, Navita
RA   Choudhary, Jyoti S.
RA   Downs, Jessica Anne
RT   "PBAF loss leads to DNA damage-induced inflammatory signaling through
RT   defective G2/M checkpoint maintenance.";
RL   Genes Dev. 36:790-806(2022).
//