ID   KTCTL-2
AC   CVCL_5871
SY   KTCTL2; KTCTL 2; RCC-EW
DR   cancercelllines; CVCL_5871
DR   CLS; 300246
DR   Cosmic; 972922
DR   Wikidata; Q54900639
RX   PubMed=7915601;
RX   PubMed=8086765;
RX   PubMed=10190320;
RX   PubMed=11720477;
RX   PubMed=11929824;
RX   PubMed=15977034;
CC   Problematic cell line: Contaminated. KTCTL-2 and KTCTL-30 have been shown to be identical (CLS; on the basis of STR profile).
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; c.341-2A>T; ClinVar=VCV002034796; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=7915601).
CC   Misspelling: KTCL2; Cosmic=972922; PubMed=7915601.
CC   Discontinued: CLS; 300246; true.
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5878 ! KTCTL-30
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=7915601; DOI=10.1038/ng0594-85;
RA   Gnarra J.R., Tory K., Weng Y.-K., Schmidt L.S., Wei M.H., Li H., Latif F.,
RA   Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.-S.R., Florence C.,
RA   Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H.,
RA   Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B.,
RA   Linehan W.M.;
RT   "Mutations of the VHL tumour suppressor gene in renal carcinoma.";
RL   Nat. Genet. 7:85-90(1994).
//
RX   PubMed=8086765; DOI=10.1007/BF00252823;
RA   Gross A.J., Wolff M., Fandrey J., Miersch W.-D.E., Dieckmann K.-P.,
RA   Jelkmann W.;
RT   "Prevalence of paraneoplastic erythropoietin production by renal cell
RT   carcinomas.";
RL   Clin. Investig. 72:337-340(1994).
//
RX   PubMed=10190320; DOI=10.1007/s004320050252;
RA   Frank M.H., Pomer S.;
RT   "Interferon alpha2b differentially affects proliferation of two human
RT   renal cell carcinoma cell lines differing in the
RT   P-glycoprotein-associated multidrug-resistant phenotype.";
RL   J. Cancer Res. Clin. Oncol. 125:117-120(1999).
//
RX   PubMed=11720477; DOI=10.1054/bjoc.2001.2074; PMCID=PMC2375251;
RA   Stassar M.J.J.G., Devitt G., Brosius M., Rinnab L., Prang J.,
RA   Schradin T., Simon J., Petersen S., Kopp-Schneider A., Zoller M.;
RT   "Identification of human renal cell carcinoma associated genes by
RT   suppression subtractive hybridization.";
RL   Br. J. Cancer 85:1372-1382(2001).
//
RX   PubMed=11929824;
RA   Batrla R., Linnebacher M., Rudy W., Stumm S., Wallwiener D.,
RA   Guckel B.;
RT   "CD40-expressing carcinoma cells induce down-regulation of CD40 ligand
RT   (CD154) and impair T-cell functions.";
RL   Cancer Res. 62:2052-2057(2002).
//
RX   PubMed=15977034; DOI=10.1007/s10334-005-0107-7;
RA   Lutz N.W., Franks S.E., Frank M.H., Pomer S., Hull W.E.;
RT   "Investigation of multidrug resistance in cultured human renal cell
RT   carcinoma cells by 31P-NMR spectroscopy and treatment survival
RT   assays.";
RL   MAGMA 18:144-161(2005).
//