AC   CVCL_5871
DR   cancercelllines; CVCL_5871
DR   CLS; 300246
DR   Cosmic; 972922
DR   Wikidata; Q54900639
RX   PubMed=7915601;
RX   PubMed=8086765;
RX   PubMed=10190320;
RX   PubMed=11720477;
RX   PubMed=11929824;
RX   PubMed=15977034;
CC   Problematic cell line: Contaminated. KTCTL-2 and KTCTL-30 have been shown to be identical (CLS; on the basis of STR profile).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; c.341-2A>T; ClinVar=VCV002034796; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=7915601).
CC   Misspelling: KTCL2; Cosmic=972922; PubMed=7915601.
CC   Discontinued: CLS; 300246; true.
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5878 ! KTCTL-30
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
RX   PubMed=7915601; DOI=10.1038/ng0594-85;
RA   Gnarra J.R., Tory K., Weng Y., Schmidt L.S., Wei M.H., Li H., Latif F.,
RA   Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C.,
RA   Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H.,
RA   Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B.,
RA   Linehan W.M.;
RT   "Mutations of the VHL tumour suppressor gene in renal carcinoma.";
RL   Nat. Genet. 7:85-90(1994).
RX   PubMed=8086765; DOI=10.1007/BF00252823;
RA   Gross A.J., Wolff M., Fandrey J., Miersch W.-D.E., Dieckmann K.-P.,
RA   Jelkmann W.;
RT   "Prevalence of paraneoplastic erythropoietin production by renal cell
RT   carcinomas.";
RL   Clin. Investig. 72:337-340(1994).
RX   PubMed=10190320; DOI=10.1007/s004320050252;
RA   Frank M.H., Pomer S.;
RT   "Interferon alpha2b differentially affects proliferation of two human
RT   renal cell carcinoma cell lines differing in the
RT   P-glycoprotein-associated multidrug-resistant phenotype.";
RL   J. Cancer Res. Clin. Oncol. 125:117-120(1999).
RX   PubMed=11720477; DOI=10.1054/bjoc.2001.2074;
RA   Stassar M.J.J.G., Devitt G., Brosius M., Rinnab L., Prang J.,
RA   Schradin T., Simon J., Petersen S., Kopp-Schneider A., Zoller M.;
RT   "Identification of human renal cell carcinoma associated genes by
RT   suppression subtractive hybridization.";
RL   Br. J. Cancer 85:1372-1382(2001).
RX   PubMed=11929824;
RA   Batrla R., Linnebacher M., Rudy W., Stumm S., Wallwiener D.,
RA   Guckel B.;
RT   "CD40-expressing carcinoma cells induce down-regulation of CD40 ligand
RT   (CD154) and impair T-cell functions.";
RL   Cancer Res. 62:2052-2057(2002).
RX   PubMed=15977034; DOI=10.1007/s10334-005-0107-7;
RA   Lutz N.W., Franks S.E., Frank M.H., Pomer S., Hull W.E.;
RT   "Investigation of multidrug resistance in cultured human renal cell
RT   carcinoma cells by 31P-NMR spectroscopy and treatment survival
RT   assays.";
RL   MAGMA 18:144-161(2005).