ID   VACO 400
AC   CVCL_5400
SY   Vaco 400; VACO-400; Vaco-400; VACO400; Vaco400; V400
DR   BTO; BTO:0004764
DR   cancercelllines; CVCL_5400
DR   Cosmic; 1312318
DR   Cosmic; 2647362
DR   GEO; GSM784046
DR   IARC_TP53; 21757
DR   Progenetix; CVCL_5400
DR   Wikidata; Q54992719
RX   PubMed=9927040;
RX   PubMed=15162061;
RX   PubMed=16418264;
RX   PubMed=18167186;
RX   PubMed=20606684;
WW   https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/VACO400.html
CC   Microsatellite instability: Stable (MSS) (PubMed=9927040).
CC   Sequence variation: Mutation; HGNC; 1148; BUB1; Unexplicit; IVS4+1G>A; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=15162061).
CC   Sequence variation: Mutation; HGNC; 16627; CHEK2; Simple; p.Thr45Thr (c.135G>A); ClinVar=VCV000186358; Zygosity=Heterozygous (PubMed=18167186).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys52Thr (c.155A>C); Zygosity=Heterozygous (PubMed=9927040).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Tyr470Asp (c.1408T>G); ClinVar=VCV000217016; Zygosity=Heterozygous (PubMed=9927040).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.74+2T>C; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=16418264).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 21
//
RX   PubMed=9927040;
RA   Grady W.M., Myeroff L.L., Swinler S.E., Rajput A., Thiagalingam S.,
RA   Lutterbaugh J.D., Neumann A., Brattain M.G., Chang J., Kim S.-J.,
RA   Kinzler K.W., Vogelstein B., Willson J.K.V., Markowitz S.D.;
RT   "Mutational inactivation of transforming growth factor beta receptor
RT   type II in microsatellite stable colon cancers.";
RL   Cancer Res. 59:320-324(1999).
//
RX   PubMed=15162061; DOI=10.1159/000077512;
RA   Grigorova M., Staines J.M., Ozdag H., Caldas C., Edwards P.A.W.;
RT   "Possible causes of chromosome instability: comparison of chromosomal
RT   abnormalities in cancer cell lines with mutations in BRCA1, BRCA2,
RT   CHK2 and BUB1.";
RL   Cytogenet. Genome Res. 104:333-340(2004).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731;
RA   Liu Y., Bodmer W.F.;
RT   "Analysis of p53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=18167186; DOI=10.5555/cmj.0366-6999.120.23.p2119.01;
RA   Liu W.-D., Zhong B.-Y., Zhang Y.-D., Choi G.-S.;
RT   "Mutation analysis of the checkpoint kinase 2 gene in colorectal
RT   cancer cell lines.";
RL   Chin. Med. J. 120:2119-2123(2007).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028;
RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//