ID   C75
AC   CVCL_5248
DR   cancercelllines; CVCL_5248
DR   CancerTools; 151758
DR   Cell_Model_Passport; SIDM01533
DR   ColonAtlas; C75
DR   Cosmic; 986008
DR   Cosmic; 995387
DR   Cosmic; 1043801
DR   Cosmic; 1312293
DR   Cosmic; 2760095
DR   DepMap; ACH-001458
DR   ECACC; 12022907
DR   GEO; GSM1374422
DR   GEO; GSM1448201
DR   IARC_TP53; 21734
DR   PRIDE; PXD005354
DR   PRIDE; PXD005355
DR   Wikidata; Q54808240
DR   Ximbio; 151758
RX   PubMed=8464898;
RX   PubMed=10737795;
RX   PubMed=16418264;
RX   PubMed=18258742;
RX   PubMed=23272949;
RX   PubMed=25926053;
RX   PubMed=29101300;
CC   Part of: AstraZeneca Colorectal cell line (AZCL) panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   HLA typing: A*01,11 (PubMed=8464898).
CC   Microsatellite instability: Stable (MSS) (PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (PubMed=16418264; DepMap=ACH-001458).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; Microarray.
CC   Discontinued: ECACC; 12022907; true.
CC   Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
ST   Source(s): DepMap=ACH-001458; ECACC=12022907; PubMed=25926053
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 10,13
ST   D16S539: 8,11
ST   D18S51: 12,14
ST   D21S11: 27,31 (DepMap=ACH-001458)
ST   D21S11: 31 (PubMed=25926053)
ST   D3S1358: 15,16
ST   D5S818: 8,12 (DepMap=ACH-001458; PubMed=25926053)
ST   D5S818: 12 (ECACC=12022907)
ST   D7S820: 9,11
ST   D8S1179: 12,13
ST   FGA: 23
ST   Penta D: 12,15
ST   Penta E: 12
ST   TH01: 8,9.3
ST   TPOX: 10
ST   vWA: 17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243;
RA   Rowan, Andrew J.
RA   Lamlum, Hanan
RA   Ilyas, Mohammad
RA   Wheeler, James M.D.
RA   Straub, Jannes
RA   Papadopoulou, Angeliki
RA   Bicknell, David C.
RA   Bodmer, Walter Fred
RA   Tomlinson, Ian Philip Mark
RT   "APC mutations in sporadic colorectal tumors: a mutational 'hotspot'
RT   and interdependence of the 'two hits'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).
//
RX   PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141;
RA   Emaduddin, Muhammad
RA   Bicknell, David C.
RA   Bodmer, Walter Fred
RA   Feller, Stephan M.
RT   "Cell growth, global phosphotyrosine elevation, and c-Met
RT   phosphorylation through Src family kinases in colorectal cancer
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).
//
RX   PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849;
RA   Schlicker, Andreas
RA   Beran, Garry
RA   Chresta, Christine M.
RA   McWalter, Gael
RA   Pritchard, Alison
RA   Weston, Susie
RA   Runswick, Sarah
RA   Davenport, Sara
RA   Heathcote, Kerry
RA   Castro, Denis Alferez
RA   Orphanides, George
RA   French, Tim
RA   Wessels, Lodewyk F.A.
RT   "Subtypes of primary colorectal tumors correlate with response to
RT   targeted treatment in colorectal cell lines.";
RL   BMC Med. Genomics 5:66.1-66.15(2012).
//
RX   PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344;
RA   Frejno, Martin
RA   Zenezini Chiozzi, Riccardo
RA   Wilhelm, Mathias
RA   Koch, Heiner
RA   Zheng, Run-Sheng
RA   Klaeger, Susan
RA   Ruprecht, Benjamin
RA   Meng, Chen
RA   Kramer, Karl
RA   Jarzab, Anna
RA   Heinzlmeir, Stephanie
RA   Johnstone, Elaine
RA   Domingo, Enric
RA   Kerr, David James
RA   Jesinghaus, Moritz
RA   Slotta-Huspenina, Julia
RA   Weichert, Wilko
RA   Knapp, Stefan
RA   Feller, Stephan M.
RA   Kuster, Bernhard
RT   "Pharmacoproteomic characterisation of human colon and rectal
RT   cancer.";
RL   Mol. Syst. Biol. 13:951-951(2017).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731;
RA   Liu, Ying
RA   Bodmer, Walter Fred
RT   "Analysis of p53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192;
RA   Browning, Michael J.
RA   Krausa, Peter
RA   Rowan, Andrew J.
RA   Bicknell, David C.
RA   Bodmer, Julia Gwynaeth
RA   Bodmer, Walter Fred
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico, Enzo
RA   Russo, Mariangela
RA   Picco, Gabriele
RA   Cancelliere, Carlotta
RA   Valtorta, Emanuele
RA   Corti, Giorgio
RA   Buscarino, Michela
RA   Isella, Claudio
RA   Lamba, Simona
RA   Martinoglio, Barbara
RA   Veronese, Silvio
RA   Siena, Salvatore
RA   Sartore-Bianchi, Andrea
RA   Beccuti, Marco
RA   Mottolese, Marcella
RA   Linnebacher, Michael
RA   Cordero, Francesca
RA   Di Nicolantonio, Federica
RA   Bardelli, Alberto
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//