ID   SK-BR-5
AC   CVCL_5217
SY   SK-Br-5; SKBR-5; SKBr5; SkBr5; SKBR5
DR   cancercelllines; CVCL_5217
DR   Cosmic; 997936
DR   Cosmic; 1046938
DR   Cosmic; 1287912
DR   Cosmic; 1289406
DR   DepMap; ACH-002329
DR   GEO; GSM421884
DR   GEO; GSM1661989
DR   IARC_TP53; 24347
DR   PharmacoDB; SKBR5_1384_2019
DR   Wikidata; Q54953625
RX   PubMed=6582512;
RX   PubMed=16397213;
RX   PubMed=16541312;
RX   PubMed=19593635;
RX   PubMed=23601657;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Sequence variation: Mutation; HGNC; HGNC:1748; CDH1; Simple; c.532-1G>C; ClinVar=VCV000406644; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Homozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Asp (c.482C>A); ClinVar=VCV000422295; Zygosity=Unspecified (PubMed=16541312).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=19593635; DOI=10.1007/s10549-009-0460-8;
RA   Hollestelle, Antoinette
RA   Nagel, Jord H.A.
RA   Smid, Marcel
RA   Lam, Suzanne
RA   Elstrodt, Fons
RA   Wasielewski, Marijke
RA   Ng, Ser Sue
RA   French, Pim J.
RA   Peeters, Justine K.
RA   Rozendaal, Marieke J.
RA   Riaz, Muhammad
RA   Koopman, Daphne G.
RA   ten Hagen, Timo L.M.
RA   de Leeuw, Bertie H.C.G.M.
RA   Zwarthoff, Ellen C.
RA   Teunisse, Amina F.A.S.
RA   van der Spek, Peter J.
RA   Klijn, Jan G.M.
RA   Dinjens, Winand N.M.
RA   Ethier, Stephen P.
RA   Clevers, Hans Cornelius
RA   Jochemsen, Aart G.
RA   den Bakker, Michael A.
RA   Foekens, John A.
RA   Martens, John W.M.
RA   Schutte, Mieke
RT   "Distinct gene mutation profiles among luminal-type and basal-type
RT   breast cancer cell lines.";
RL   Breast Cancer Res. Treat. 121:53-64(2010).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720;
RA   Mattes, Michael Jules
RA   Cordon-Cardo, Carlos
RA   Lewis, John L. Jr.
RA   Old, Lloyd John
RA   Lloyd, Kenneth Oliver
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661;
RA   Riaz, Muhammad
RA   van Jaarsveld, Marijn T.M.
RA   Hollestelle, Antoinette
RA   Prager-van der Smissen, Wendy J.C.
RA   Heine, Anouk A.J.
RA   Boersma, Antonius W.M.
RA   Liu, Jing-Jing
RA   Helmijr, Jean C.A.
RA   Ozturk, Bahar
RA   Smid, Marcel
RA   Wiemer, Erik A.C.
RA   Foekens, John A.
RA   Martens, John W.M.
RT   "miRNA expression profiling of 51 human breast cancer cell lines
RT   reveals subtype and driver mutation-specific miRNAs.";
RL   Breast Cancer Res. 15:R33.1-R33.17(2013).
//
RX   PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853;
RA   Elstrodt, Fons
RA   Hollestelle, Antoinette
RA   Nagel, Jord H.A.
RA   Gorin, Michael
RA   Wasielewski, Marijke
RA   van den Ouweland, Ans M.W.
RA   Merajver, Sofia Diana
RA   Ethier, Stephen P.
RA   Schutte, Mieke
RT   "BRCA1 mutation analysis of 41 human breast cancer cell lines reveals
RT   three new deleterious mutants.";
RL   Cancer Res. 66:41-45(2006).
//
RX   PubMed=16541312; DOI=10.1007/s10549-006-9186-z;
RA   Wasielewski, Marijke
RA   Elstrodt, Fons
RA   Klijn, Jan G.M.
RA   Berns, Els M.J.J.
RA   Schutte, Mieke
RT   "Thirteen new p53 gene mutants identified among 41 human breast cancer
RT   cell lines.";
RL   Breast Cancer Res. Treat. 99:97-101(2006).
//