ID   INA-6
AC   CVCL_5209
SY   INA6
DR   BTO; BTO_0004745
DR   EFO; EFO_0005386
DR   BioSample; SAMN10989605
DR   cancercelllines; CVCL_5209
DR   Cell_Model_Passport; SIDM01555
DR   Cosmic; 1424216
DR   Cosmic; 1483075
DR   Cosmic; 2081383
DR   DepMap; ACH-000512
DR   DSMZ; ACC-862
DR   DSMZCellDive; ACC-862
DR   Wikidata; Q54897699
RX   CelloPub=CLPUB00060;
RX   CelloPub=CLPUB00604;
RX   PubMed=10936422;
RX   PubMed=11920233;
RX   PubMed=17692805;
RX   PubMed=18647998;
RX   PubMed=19621390;
RX   PubMed=22806891;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=32123307;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=INA-6
WW   Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Characteristics: Produces Ig kappa.
CC   Characteristics: IL6 dependent.
CC   Doubling time: ~30-50 hours (DSMZ=ACC-862).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (DepMap=ACH-000512).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Met (c.395A>T); ClinVar=VCV000376629; Zygosity=Heterozygous (DepMap=ACH-000512).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Heterozygous (DepMap=ACH-000512).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Genome ancestry: African=0.46%; Native American=0.15%; East Asian, North=2.2%; East Asian, South=0%; South Asian=0%; European, North=63.38%; European, South=33.82% (PubMed=30894373).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Plasma cell; CL=CL_0000786.
ST   Source(s): DSMZ=ACC-862
ST   Amelogenin: X,Y
ST   CSF1PO: 10,13
ST   D13S317: 8,12
ST   D16S539: 9,11
ST   D18S51: 12,15
ST   D19S433: 14,15
ST   D21S11: 29,30
ST   D2S1338: 16
ST   D3S1358: 15,16
ST   D5S818: 12,13
ST   D7S820: 11,12
ST   D8S1179: 14
ST   FGA: 21,22
ST   Penta D: 9
ST   Penta E: 7,12
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   80Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 31
CH   CVCL_0C40 ! INA-6.Tu1
//
RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler, Hans Gunther
RA   Matsuo, Yoshinobu
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
//
RX   CelloPub=CLPUB00604;
RA   Chow, Sharon
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017); University of Toronto; Toronto; Canada.
//
RX   PubMed=22806891; DOI=10.1182/blood-2011-08-371567;
RA   Holien, Toril
RA   Vatsveen, Thea Kristin
RA   Hella, Hanne
RA   Waage, Anders
RA   Sundan, Anders
RT   "Addiction to c-MYC in multiple myeloma.";
RL   Blood 120:2450-2453(2012).
//
RX   PubMed=19621390; DOI=10.1002/ijc.24758;
RA   Guenther, Andreas
RA   Gordon, Sharon
RA   Tiemann, Markus
RA   Burger, Renate
RA   Bakker, Frank
RA   Green, Jon R.
RA   Baum, Wolfgang
RA   Roelofs, Anke J.
RA   Rogers, Michael J.
RA   Gramatzki, Martin
RT   "The bisphosphonate zoledronic acid has antimyeloma activity in vivo
RT   by inhibition of protein prenylation.";
RL   Int. J. Cancer 126:239-246(2010).
//
RX   PubMed=11920233; DOI=10.1038/sj.thj.6200075;
RA   Burger, Renate
RA   Guenther, Andreas
RA   Bakker, Frank
RA   Schmalzing, Marc
RA   Bernand, Sabrina
RA   Baum, Wolfgang
RA   Duerr, Birgit
RA   Hocke, Gertrud M.
RA   Steininger, Helmuth
RA   Gebhart, Erich
RA   Gramatzki, Martin
RT   "Gp130 and ras mediated signaling in human plasma cell line INA-6: a
RT   cytokine-regulated tumor model for plasmacytoma.";
RL   Hematol. J. 2:42-53(2001).
//
RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300;
RA   Sarin, Vishesh
RA   Yu, Katharine
RA   Ferguson, Ian D.
RA   Gugliemini, Olivia
RA   Nix, Matthew A.
RA   Hann, Byron
RA   Sirota, Marina
RA   Wiita, Arun P.
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698;
RA   Keats, Jonathan J.
RA   Fonseca, Rafael
RA   Chesi, Marta
RA   Schop, Roelandt
RA   Baker, Angela
RA   Chng, Wee-Joo
RA   Van Wier, Scott
RA   Tiedemann, Rodger
RA   Shi, Chang-Xin
RA   Sebag, Michael
RA   Braggio, Esteban
RA   Henry, Travis
RA   Zhu, Yuan-Xiao
RA   Fogle, Homer
RA   Price-Troska, Tammy L.
RA   Ahmann, Gregory J.
RA   Mancini, Catherine
RA   Brents, Leslie A.
RA   Kumar, Shaji K.
RA   Greipp, Philip Robert
RA   Dispenzieri, Angela
RA   Bryant, Barb
RA   Mulligan, George
RA   Bruhn, Laurakay
RA   Barrett, Michael T.
RA   Valdez, Riccardo
RA   Trent, Jeffrey M.
RA   Stewart, A. Keith
RA   Carpten, John D.
RA   Bergsagel, Peter Leif
RT   "Promiscuous mutations activate the noncanonical NF-kappaB pathway in
RT   multiple myeloma.";
RL   Cancer Cell 12:131-144(2007).
//
RX   PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184;
RA   Dib, Amel
RA   Gabrea, Ana
RA   Glebov, Oleg K.
RA   Bergsagel, Peter Leif
RA   Kuehl, Walter Michael
RT   "Characterization of MYC translocations in multiple myeloma cell
RT   lines.";
RL   J. Natl. Cancer Inst. Monogr. 39:25-31(2008).
//
RX   CelloPub=CLPUB00060;
RA   Gramatzki, Martin
RA   Burger, Renate
RA   Trautmann, Udo
RA   Marschalek, Rolf
RA   Lorenz, Hans-Martin
RA   Hansen-Hagge, Thomas E.
RA   Baum, Wolfgang
RA   Bartram, Claus Rainer
RA   Gebhart, Erich
RA   Kalden, Joachim Robert
RT   "Two new interleukin-6 dependent plasma cell lines carrying a
RT   chromosomal abnormality involving the IL-6 gene locus.";
RL   Blood 84 Suppl. 1:173a.678-173a.678(1994).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//