ID   HCC1195
AC   CVCL_5127
SY   HCC-1195; Hamon Cancer Center 1195
DR   EFO; EFO_0005371
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10988074
DR   cancercelllines; CVCL_5127
DR   Cell_Model_Passport; SIDM01607
DR   Cosmic; 903636
DR   Cosmic; 1146925
DR   Cosmic; 1925842
DR   DepMap; ACH-000868
DR   GEO; GSM62337
DR   GEO; GSM253429
DR   GEO; GSM434298
DR   GEO; GSM794385
DR   GEO; GSM817119
DR   GEO; GSM887036
DR   GEO; GSM888106
DR   IARC_TP53; 11448
DR   IGRhCellID; HCC1195_02GEO
DR   KCLB; 71195
DR   LiGeA; CCLE_352
DR   PharmacoDB; HCC1195_447_2019
DR   Progenetix; CVCL_5127
DR   Wikidata; Q54881541
RX   PubMed=10353731;
RX   PubMed=16187286;
RX   PubMed=20624269;
RX   PubMed=20679594;
RX   PubMed=22460905;
RX   PubMed=22961666;
RX   PubMed=26589293;
RX   PubMed=28196595;
RX   PubMed=29681454;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31803961;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Provider; UT Southwestern; -; https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: African American.
CC   Doubling time: 70.4 hours (PubMed=29681454).
CC   HLA typing: A*30:01,33:03; B*42:02,58:02; C*06:02,17:01; DQB1*06:13,06:13 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (DepMap=ACH-000868).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly262_Asn263delinsProAsp (c.784_789del6insCCTGAT); Zygosity=Heterozygous (PubMed=10353731; DepMap=ACH-000868).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=70.13%; Native American=0%; East Asian, North=4.8%; East Asian, South=0%; South Asian=0%; European, North=6.41%; European, South=18.66% (PubMed=30894373).
CC   Miscellaneous: Direct author submission of STR profile from Girard, Luc & Gazdar, Adi F.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): Direct_author_submission; KCLB=71195; PubMed=20679594
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 9
ST   D21S11: 29
ST   D3S1358: 15,16
ST   D5S818: 13
ST   D7S820: 10,11
ST   FGA: 21
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C9133; Lung adenosquamous carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   47Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 32
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474;
RA   Gazdar, Adi F.
RA   Girard, Luc
RA   Lockwood, William W.
RA   Lam, Wan L.
RA   Minna, John D.
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=16187286; DOI=10.1002/ijc.21491;
RA   Garnis, Cathie
RA   Lockwood, William W.
RA   Vucic, Emily
RA   Ge, Ying
RA   Girard, Luc
RA   Minna, John D.
RA   Gazdar, Adi F.
RA   Lam, Stephen
RA   MacAulay, Calum
RA   Lam, Wan L.
RT   "High resolution analysis of non-small cell lung cancer cell lines by
RT   whole genome tiling path array CGH.";
RL   Int. J. Cancer 118:1556-1564(2006).
//
RX   PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540;
RA   McMillan, Elizabeth A.
RA   Ryu, Myung-Jeom
RA   Diep, Caroline H.
RA   Mendiratta, Saurabh
RA   Clemenceau, Jean Rene
RA   Vaden, Rachel M.
RA   Kim, Ju-Hwa
RA   Motoyaji, Takashi
RA   Covington, Kyle R.
RA   Peyton, Michael
RA   Huffman, Kenneth
RA   Wu, Xiao-Feng
RA   Girard, Luc
RA   Sung, Yeojin
RA   Chen, Pei-Hsaun
RA   Mallipeddi, Prema Latha
RA   Lee, Joo Young
RA   Hanson, Jordan
RA   Voruganti, Sukesh
RA   Yu, Yunku
RA   Park, Sunho
RA   Sudderth, Jessica
RA   DeSevo, Christopher
RA   Muzny, Donna M.
RA   Doddapaneni, HarshaVardhan
RA   Gazdar, Adi F.
RA   Gibbs, Richard Alexander
RA   Hwang, Tae Hyun
RA   Heymach, John Victor
RA   Wistuba, Ignacio Ivan
RA   Coombes, Kevin Robert
RA   Williams, Noelle S.
RA   Wheeler, David A.
RA   MacMillan, John B.
RA   DeBerardinis, Ralph J.
RA   Roth, Michael G.
RA   Posner, Bruce Arthur
RA   Minna, John D.
RA   Kim, Hyun Seok
RA   White, Michael A.
RT   "Chemistry-first approach for nomination of personalized treatment in
RT   lung cancer.";
RL   Cell 173:864-878.e29(2018).
//
RX   PubMed=10353731;
RA   Wistuba, Ignacio Ivan
RA   Bryant, David
RA   Behrens, Carmen
RA   Milchgrub, Sara
RA   Virmani, Arvind K.
RA   Ashfaq, Raheela
RA   Minna, John D.
RA   Gazdar, Adi F.
RT   "Comparison of features of human lung cancer cell lines and their
RT   corresponding tumors.";
RL   Clin. Cancer Res. 5:991-1000(1999).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922;
RA   Byers, Lauren Averett
RA   Wang, Jing
RA   Nilsson, Monique B.
RA   Fujimoto, Junya
RA   Saintigny, Pierre
RA   Yordy, John Stuart
RA   Giri, Uma
RA   Peyton, Michael
RA   Fan, You-Hong
RA   Diao, Li-Xia
RA   Masrorpour, Fatemeh
RA   Shen, Li
RA   Liu, Wen-Bin
RA   Duchemann, Boris
RA   Tumula, Praveen
RA   Bhardwaj, Vikas
RA   Welsh, James
RA   Weber, Stephanie
RA   Glisson, Bonnie S.
RA   Kalhor, Neda
RA   Wistuba, Ignacio Ivan
RA   Girard, Luc
RA   Lippman, Scott M.
RA   Mills, Gordon B.
RA   Coombes, Kevin Robert
RA   Weinstein, John N.
RA   Minna, John D.
RA   Heymach, John Victor
RT   "Proteomic profiling identifies dysregulated pathways in small cell
RT   lung cancer and novel therapeutic targets including PARP1.";
RL   Cancer Discov. 2:798-811(2012).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, A. Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339;
RA   Du, Li-Qin
RA   Schageman, Jeoffrey J.
RA   Irnov, Irnov
RA   Girard, Luc
RA   Hammond, Scott M.
RA   Minna, John D.
RA   Gazdar, Adi F.
RA   Pertsemlidis, Alexander
RT   "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells
RT   and suggests a possible pathological relationship between SCLCs and
RT   NSCLCs.";
RL   J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).
//