ID   SNU-886
AC   CVCL_5103
SY   SNU886; NCI-SNU-886
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10988057
DR   cancercelllines; CVCL_5103
DR   Cell_Model_Passport; SIDM01434
DR   Cosmic; 2771604
DR   DepMap; ACH-000316
DR   GEO; GSM888733
DR   GEO; GSM1374901
DR   GEO; GSM2551594
DR   IARC_TP53; 6314
DR   KCLB; 00886
DR   LiGeA; CCLE_720
DR   LIMORE; SNU886
DR   PharmacoDB; SNU886_1487_2019
DR   Progenetix; CVCL_5103
DR   Wikidata; Q54955282
RX   PubMed=8824565;
RX   PubMed=11819450;
RX   PubMed=19956504;
RX   PubMed=22460905;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31063779;
RX   PubMed=31068700;
RX   PubMed=31378681;
WW   Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/SNU886
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Liver Cancer Model Repository (LIMORE).
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Population: Korean.
CC   Doubling time: 29 hours (PubMed=11819450); 25.19 hours (PubMed=31378681).
CC   HLA typing: A*24:02,33:03; B*13:02,44:03; C*06:02,07:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220fs*27 (c.655delC) (p.P219Lfs); Zygosity=Homozygous (PubMed=8824565; DepMap=ACH-000316).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.56%; Native American=0.92%; East Asian, North=64.25%; East Asian, South=33.26%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): KCLB=00886; PubMed=31378681
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8,9
ST   D16S539: 10
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 11,12
ST   FGA: 21,24
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 14,20
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001;
RA   Caruso, Stefano
RA   Calatayud, Anna-Line
RA   Pilet, Jill
RA   La Bella, Tiziana
RA   Rekik, Samia
RA   Imbeaud, Sandrine
RA   Letouze, Eric
RA   Meunier, Lea
RA   Bayard, Quentin
RA   Rohr-Udilova, Nataliya
RA   Peneau, Camille
RA   Grasl-Kraupp, Bettina
RA   de Koning, Leanne
RA   Ouine, Berengere
RA   Bioulac-Sage, Paulette
RA   Couchy, Gabrielle
RA   Calderaro, Julien
RA   Nault, Jean-Charles
RA   Zucman-Rossi, Jessica
RA   Rebouissou, Sandra
RT   "Analysis of liver cancer cell lines identifies agents with likely
RT   efficacy against hepatocellular carcinoma and markers of response.";
RL   Gastroenterology 157:760-776(2019).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724;
RA   Qiu, Zhi-Xin
RA   Li, Hong
RA   Zhang, Zheng-Tao
RA   Zhu, Zhen-Feng
RA   He, Sheng
RA   Wang, Xu-Jun
RA   Wang, Peng-Cheng
RA   Qin, Jian-Jie
RA   Zhuang, Li-Ping
RA   Wang, Wei
RA   Xie, Fu-Bo
RA   Gu, Ying
RA   Zou, Ke-Ke
RA   Li, Chao
RA   Li, Chun
RA   Wang, Chen-Hua
RA   Cen, Jin
RA   Chen, Xiao-Tao
RA   Shu, Ya-Jing
RA   Zhang, Zhao
RA   Sun, Lu-Lu
RA   Min, Li-Hua
RA   Fu, Yong
RA   Huang, Xiao-Wu
RA   Lv, Hui
RA   Zhou, He
RA   Ji, Yuan
RA   Zhang, Zhi-Gang
RA   Meng, Zhi-Qiang
RA   Shi, Xiao-Lei
RA   Zhang, Hai-Bin
RA   Li, Yi-Xue
RA   Hui, Li-Jian
RT   "A pharmacogenomic landscape in human liver cancers.";
RL   Cancer Cell 36:179-193.e11(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X;
RA   Kang, Myung-Soo
RA   Lee, Hong-Joo
RA   Lee, Jae-Ho
RA   Ku, Ja-Lok
RA   Lee, Kathreen P.
RA   Kelley, Michael J.
RA   Won, Yong-Jin
RA   Kim, Soo-Tae
RA   Park, Jae-Gahb
RT   "Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX
RT   DNA.";
RL   Int. J. Cancer 67:898-902(1996).
//
RX   PubMed=11819450; DOI=10.3748/wjg.v5.i4.289; PMCID=PMC4695537;
RA   Lee, Jae-Ho
RA   Ku, Ja-Lok
RA   Park, Young-Jin
RA   Lee, Kuhn-Uk
RA   Kim, Woo-Ho
RA   Park, Jae-Gahb
RT   "Establishment and characterization of four human hepatocellular
RT   carcinoma cell lines containing hepatitis B virus DNA.";
RL   World J. Gastroenterol. 5:289-295(1999).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416;
RA   Ku, Ja-Lok
RA   Park, Jae-Gahb
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//