ID   SNU-245
AC   CVCL_5038
SY   SNU245; NCI-SNU-245
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10988083
DR   cancercelllines; CVCL_5038
DR   Cell_Model_Passport; SIDM00162
DR   Cosmic; 738866
DR   Cosmic; 2674052
DR   DepMap; ACH-000268
DR   GEO; GSM887618
DR   GEO; GSM888702
DR   IARC_TP53; 28357
DR   KCLB; 00245
DR   LiGeA; CCLE_733
DR   PharmacoDB; SNU245_1452_2019
DR   Progenetix; CVCL_5038
DR   Wikidata; Q54955153
RX   CelloPub=CLPUB00275;
RX   PubMed=12107841;
RX   PubMed=19956504;
RX   PubMed=22460905;
RX   PubMed=26589293;
RX   PubMed=27231123;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31395879;
RX   PubMed=35640676;
RX   PubMed=39026794;
CC   Part of: Biliary tract cancer cell line atlas.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Part of: TCGA-110-CL cell line panel.
CC   Population: Korean.
CC   Doubling time: 54 hours (PubMed=12107841).
CC   HLA typing: A*02:01,33:03; B*35:01,44:03; C*03:03,14:03 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (DepMap=ACH-000268).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.84%; Native American=0.55%; East Asian, North=65.45%; East Asian, South=33.11%; South Asian=0%; European, North=0%; European, South=0.05% (PubMed=30894373).
CC   Derived from site: In situ; Bile duct; UBERON=UBERON_0002394.
ST   Source(s): KCLB=00245
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9,13
ST   D16S539: 9,13
ST   D18S51: 16
ST   D19S433: 14,15.2
ST   D21S11: 27,30
ST   D2S1338: 18,19
ST   D3S1358: 17,19
ST   D5S818: 7
ST   D7S820: 8,10
ST   D8S1179: 13,15
ST   FGA: 21.2,24
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C4436; Cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737;
RA   Saha, Supriya Kumar
RA   Gordan, John D.
RA   Kleinstiver, Benjamin P.
RA   Vu, Phuong
RA   Najem, Mortada S.
RA   Yeo, Jia-Chi
RA   Shi, Lei
RA   Kato, Yasutaka
RA   Levin, Rebecca S.
RA   Webber, James T.
RA   Damon, Leah J.
RA   Egan, Regina K.
RA   Greninger, Patricia
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RA   Jenkins, Roger L.
RA   Rieger-Christ, Kimberly M.
RA   Sullivan, Travis B.
RA   Hezel, Aram Francis
RA   Liss, Andrew S.
RA   Mizukami, Yusuke
RA   Goyal, Lipika
RA   Ferrone, Cristina Rosa
RA   Zhu, Andrew Xiu-Xuan
RA   Joung, Jae Keith
RA   Shokat, Kevan Michael
RA   Benes, Cyril Henri
RA   Bardeesy, Nabeel M.
RT   "Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity
RT   and SRC dependence in intrahepatic cholangiocarcinoma.";
RL   Cancer Discov. 6:727-739(2016).
//
RX   PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785;
RA   Yu, Katharine
RA   Chen, Bin
RA   Aran, Dvir
RA   Charalel, Joe
RA   Yau, Christina
RA   Wolf, Douglas M.
RA   van 't Veer, Laura J.
RA   Butte, Atul Janardhan
RA   Goldstein, Ted
RA   Sirota, Marina
RT   "Comprehensive transcriptomic analysis of cell lines as models of
RT   primary tumors across 22 tumor types.";
RL   Nat. Commun. 10:3574.1-3574.11(2019).
//
RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155;
RA   Isidan, Abdulkadir
RA   Yenigun, Ali
RA   Soma, Daiki
RA   Aksu, Eric
RA   Lopez, Kevin
RA   Park, Yujin
RA   Cross-Najafi, Arthur
RA   Li, Ping
RA   Kundu, Debjyoti
RA   House, Michael G.
RA   Chakraborty, Sanjukta
RA   Glaser, Shannon
RA   Kennedy, Lindsey
RA   Francis, Heather
RA   Zhang, Wen-Jun
RA   Alpini, Gianfranco D.
RA   Ekser, Burcin
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=12107841; DOI=10.1038/sj.bjc.6600440; PMCID=PMC2376107;
RA   Ku, Ja-Lok
RA   Yoon, Kyong-Ah
RA   Kim, Il-Jin
RA   Kim, Woo-Ho
RA   Jang, Jin-Young
RA   Suh, Kyung-Suk
RA   Kim, Sun-Whe
RA   Park, Yong-Hyun
RA   Hwang, Jae-Ho
RA   Yoon, Yong-Bum
RA   Park, Jae-Gahb
RT   "Establishment and characterisation of six human biliary tract cancer
RT   cell lines.";
RL   Br. J. Cancer 87:187-193(2002).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448;
RA   Vijay, Vindhya
RA   Karisani, Negin
RA   Shi, Lei
RA   Hung, Yu-Han
RA   Vu, Phuong
RA   Kattel, Prabhat
RA   Kenney, Lauren
RA   Merritt, Joshua
RA   Adil, Ramzi
RA   Wu, Qi-Biao
RA   Zhen, Yuan-Li
RA   Morris, Robert
RA   Kreuzer, Johannes
RA   Kathiresan, Meena
RA   Herrera Lopez, Xcanda Ixchel
RA   Ellis, Haley
RA   Gritti, Ilaria G.
RA   Lecorgne, Lilian
RA   Farag, Ines
RA   Popa, Alexandra
RA   Shen, William
RA   Kato, Hiroyuki
RA   Xu, Qin
RA   Balasooriya, Eranga Roshan
RA   Wu, Meng-Ju
RA   Chaturantabut, Saireudee
RA   Kelley, Robin Kate
RA   Cleary, James Mark
RA   Lawrence, Michael Scott
RA   Root, David E.
RA   Benes, Cyril Henri
RA   Deshpande, Vikram
RA   Juric, Dejan
RA   Sellers, William Raj
RA   Ferrone, Cristina Rosa
RA   Haas, Wilhelm
RA   Vazquez, Francisca
RA   Getz, Gad
RA   Bardeesy, Nabeel M.
RT   "Generation of a biliary tract cancer cell line atlas reveals
RT   molecular subtypes and therapeutic targets.";
RL   bioRxiv 2024:07.04.601970-07.04.601970(2024).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416;
RA   Ku, Ja-Lok
RA   Park, Jae-Gahb
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   CelloPub=CLPUB00275;
RA   Zach, Sebastian
RA   Birgin, Emrullah
RA   Ruckert, Felix
RT   "Primary cholangiocellular carcinoma cell lines.";
RL   J. Stem Cell Res. Transplant. 2:1013-1013(2015).
//