ID   MT-CHC01
AC   CVCL_4Z41
DR   cancercelllines; CVCL_4Z41
DR   GEO; GSM3209135
DR   GEO; GSM3209136
DR   Wikidata; Q54906955
RX   PubMed=26486326;
RX   PubMed=30979003;
RX   PubMed=35640676;
CC   Population: Caucasian; Italian.
CC   Characteristics: Established from a mouse xenograft (PubMed=26486326).
CC   Doubling time: ~40 hours (PubMed=26486326); 25.3 hours (PubMed=30979003).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=26486326).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C35417; Intrahepatic cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   60Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 10-04-25; Version: 16
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RX   PubMed=26486326; DOI=10.1007/s13277-015-4215-3; PMCID=PMC4844644;
RA   Cavalloni G., Peraldo-Neia C., Varamo C., Casorzo L., Dell'Aglio C.,
RA   Bernabei P., Chiorino G., Aglietta M., Leone F.;
RT   "Establishment and characterization of a human intrahepatic
RT   cholangiocarcinoma cell line derived from an Italian patient.";
RL   Tumor Biol. 37:4041-4052(2016).
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RX   PubMed=30979003; DOI=10.3390/cancers11040519; PMCID=PMC6520787;
RA   Varamo C., Peraldo-Neia C., Ostano P., Basirico M., Raggi C.,
RA   Bernabei P., Venesio T., Berrino E., Aglietta M., Leone F.,
RA   Cavalloni G.;
RT   "Establishment and characterization of a new intrahepatic
RT   cholangiocarcinoma cell line resistant to gemcitabine.";
RL   Cancers (Basel) 11:519.1-519.22(2019).
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RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155;
RA   Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y.,
RA   Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S.,
RA   Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.;
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//