ID   DU-145 R
AC   CVCL_4Y36
DR   cancercelllines; CVCL_4Y36
DR   Wikidata; Q54831571
RX   PubMed=21982118;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0105 ! DU145
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 19-12-24; Version: 15
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RX   PubMed=21982118; DOI=10.1186/1476-4598-10-126; PMCID=PMC3203088;
RA   O'Neill, Amanda J.
RA   Prencipe, Maria
RA   Dowling, Catherine
RA   Fan, Yue
RA   Mulrane, Laoighse
RA   Gallagher, William M.
RA   O'Connor, Darran
RA   O'Connor, Robert
RA   Devery, Aoife Maire
RA   Corcoran, Claire
RA   Rani, Sweta
RA   O'Driscoll, Lorraine
RA   Fitzpatrick, John Michael
RA   Watson, R. William G.
RT   "Characterisation and manipulation of docetaxel resistant prostate
RT   cancer cell lines.";
RL   Mol. Cancer 10:126.1-126.13(2011).
//