ID   K562/ara-C
AC   CVCL_4V20
DR   Wikidata; Q54899404
RX   PubMed=21290089;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_28680; Cytarabine (Arabinosylcytosine; Ara-C).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 19-12-24; Version: 17
//
RX   PubMed=21290089; DOI=10.3892/ijo.2011.933;
RA   Negoro E., Yamauchi T., Urasaki Y., Nishi R., Hori H., Ueda T.;
RT   "Characterization of cytarabine-resistant leukemic cell lines
RT   established from five different blood cell lineages using gene
RT   expression and proteomic analyses.";
RL   Int. J. Oncol. 38:911-919(2011).
//