ID   HBMEC/cibeta
AC   CVCL_4U95
SY   HBMEC/cib; Human BMEC/conditionally immortalized, clone beta
DR   Wikidata; Q54881448
RX   PubMed=23041702;
RX   PubMed=25763180;
RX   PubMed=30983357;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Proteomics; Subcellular; Membrane; Quantitative.
CC   Derived from site: In situ; Brain, endothelium; UBERON=UBERON_0013694.
CC   Cell type: Brain microvascular endothelial cell; CL=CL_2000044.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
CA   Conditionally immortalized cell line
DT   Created: 14-12-15; Last updated: 10-04-25; Version: 13
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RX   PubMed=23041702; DOI=10.1016/j.brainres.2012.09.042;
RA   Kamiichi A., Furihata T., Kishida S., Ohta Y., Saito K., Kawamatsu S.,
RA   Chiba K.;
RT   "Establishment of a new conditionally immortalized cell line from
RT   human brain microvascular endothelial cells: a promising tool for
RT   human blood-brain barrier studies.";
RL   Brain Res. 1488:113-122(2012).
//
RX   PubMed=25763180; DOI=10.1186/s12987-015-0003-0; PMCID=PMC4355132;
RA   Furihata T., Kawamatsu S., Ito R., Saito K., Suzuki S., Kishida S.,
RA   Saito Y., Kamiichi A., Chiba K.;
RT   "Hydrocortisone enhances the barrier properties of HBMEC/cibeta, a
RT   brain microvascular endothelial cell line, through
RT   mesenchymal-to-endothelial transition-like effects.";
RL   Fluids Barriers CNS 12:7.1-7.15(2015).
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RX   PubMed=30983357; DOI=10.1021/acs.molpharmaceut.9b00114;
RA   Masuda T., Hoshiyama T., Uemura T., Hirayama-Kurogi M., Ogata S.,
RA   Furukawa A., Couraud P.-O., Furihata T., Ito S., Ohtsuki S.;
RT   "Large-scale quantitative comparison of plasma transmembrane proteins
RT   between two human blood-brain barrier model cell lines, hCMEC/D3 and
RT   HBMEC/cibeta.";
RL   Mol. Pharm. 16:2162-2171(2019).
//