ID   GLC-4/CDDP
AC   CVCL_4998
SY   GLC4-CDDP; GLC4/CDDP; GLC4/cDDP
DR   BTO; BTO_0002388
DR   cancercelllines; CVCL_4998
DR   Cosmic; 1998275
DR   GEO; GSM536325
DR   Progenetix; CVCL_4998
DR   Wikidata; Q54835915
RX   PubMed=1657425;
RX   PubMed=2163989;
RX   PubMed=2846161;
RX   PubMed=12093475;
RX   PubMed=20615970;
CC   Doubling time: 43 +- 3 hours (PubMed=2846161).
CC   Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0279 ! GLC-4
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 21
//
RX   PubMed=2846161;
RA   Hospers, Geke A.P.
RA   Mulder, Nanno H.
RA   de Jong, Bauke
RA   de Leij, Lou F.M.H.
RA   Uges, Donald Robert Alexander
RA   Fichtinger-Schepman, Anne Marie Josephine
RA   Scheper, Riekeld J.
RA   de Vries, Elisabeth Geertruida Emma
RT   "Characterization of a human small cell lung carcinoma cell line with
RT   acquired resistance to cis-diamminedichloroplatinum(II) in vitro.";
RL   Cancer Res. 48:6803-6807(1988).
//
RX   PubMed=12093475; DOI=10.1016/S0006-2952(02)00983-8;
RA   Fokkema, Eelco
RA   Groen, Harry J.M.
RA   Helder, Marco N.
RA   de Vries, Elisabeth Geertruida Emma
RA   Meijer, Coby
RT   "JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to
RT   platinum-DNA adduct formation, glutathione levels and p53 status in
RT   human tumour cell lines with different sensitivities to cisplatin.";
RL   Biochem. Pharmacol. 63:1989-1996(2002).
//
RX   PubMed=1657425; DOI=10.1007/BF00685823;
RA   de Jong, Steven
RA   Zijlstra, Jan G.
RA   Mulder, Nanno H.
RA   de Vries, Elisabeth Geertruida Emma
RT   "Lack of cross-resistance to fostriecin in a human small-cell lung
RT   carcinoma cell line showing topoisomerase II-related drug resistance.";
RL   Cancer Chemother. Pharmacol. 28:461-464(1991).
//
RX   PubMed=20615970; DOI=10.1073/pnas.1008132107; PMCID=PMC2919980;
RA   Voortman, Johannes
RA   Lee, Jih-Hsiang
RA   Killian, Jonathan Keith
RA   Suuriniemi, Miia
RA   Wang, Yong-Hong
RA   Lucchi, Marco
RA   Smith, William I. Jr.
RA   Meltzer, Paul S.
RA   Wang, Yi-Song
RA   Giaccone, Giuseppe
RT   "Array comparative genomic hybridization-based characterization of
RT   genetic alterations in pulmonary neuroendocrine tumors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:13040-13045(2010).
//
RX   PubMed=2163989; DOI=10.1002/ijc.2910460125;
RA   Hospers, Geke A.P.
RA   Meijer, Coby
RA   de Leij, Lou F.M.H.
RA   Uges, Donald Robert Alexander
RA   Mulder, Nanno H.
RA   de Vries, Elisabeth Geertruida Emma
RT   "A study of human small-cell lung carcinoma (hSCLC) cell lines with
RT   different sensitivities to detect relevant mechanisms of cisplatin
RT   (CDDP) resistance.";
RL   Int. J. Cancer 46:138-144(1990).
//