ID   MS751
AC   CVCL_4996
SY   MS-751; MS 751
DR   CLO; CLO_0007878
DR   EFO; EFO_0006456
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-34
DR   BioSample; SAMN03472742
DR   BioSample; SAMN03473089
DR   cancercelllines; CVCL_4996
DR   CCRID; 3101HUMSCSP537
DR   CCRID; 3101HUMTCHu178
DR   Cell_Model_Passport; SIDM00638
DR   CLS; 305115
DR   Cosmic; 928910
DR   Cosmic; 1071904
DR   Cosmic; 1131523
DR   Cosmic; 1176606
DR   Cosmic; 1193034
DR   Cosmic; 1201772
DR   Cosmic; 1995514
DR   Cosmic; 2816216
DR   Cosmic-CLP; 1240179
DR   DepMap; ACH-001360
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 1240179
DR   GEO; GSM113865
DR   GEO; GSM253301
DR   GEO; GSM675737
DR   GEO; GSM685439
DR   GEO; GSM1670135
DR   IARC_TP53; 27233
DR   IGRhCellID; MS751
DR   LINCS_LDP; LCL-1306
DR   PharmacoDB; MS751_967_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_4996
DR   Ubigene; YC-C123
DR   Wikidata; Q54906811
RX   PubMed=327080;
RX   PubMed=2990217;
RX   PubMed=3518877;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=9049418;
RX   PubMed=15531914;
RX   PubMed=24134916;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Virology: Contains a partial HPV45 genome.
CC   Doubling time: 2.4 days (PubMed=29156801).
CC   HLA typing: A*02:01,24:02; B*35:03,40:01; C*03:04,12:03 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Transformant: NCBI_TaxID; 10593; Human papillomavirus type 45 (HPV45).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0.44%; East Asian, North=0%; East Asian, South=0.42%; South Asian=0.41%; European, North=67.07%; European, South=31.66% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): ATCC; CCRID; Cosmic-CLP; DepMap; PubMed=25877200; PubMed=29156801
ST   Amelogenin: X
ST   CSF1PO: 11 (CCRID; PubMed=25877200)
ST   CSF1PO: 11,12 (ATCC; Cosmic-CLP; DepMap; PubMed=29156801)
ST   D13S317: 12
ST   D16S539: 11
ST   D18S51: 12
ST   D19S433: 16
ST   D21S11: 29,30
ST   D2S1338: 22
ST   D3S1358: 19
ST   D5S818: 12
ST   D7S820: 9,11
ST   D8S1179: 14
ST   FGA: 20
ST   Penta D: 9
ST   Penta E: 12
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 16
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 36
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=2990217;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=9049418; DOI=10.1099/0022-1317-78-3-655;
RA   Geisbill J., Osmers U., Durst M.;
RT   "Detection and characterization of human papillomavirus type 45 DNA in
RT   the cervical carcinoma cell line MS751.";
RL   J. Gen. Virol. 78:655-658(1997).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44;
RA   McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C.,
RA   Duesberg P.H.;
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//