ID   Sq-1
AC   CVCL_4900
SY   SQ-1; SQ1; Sq1
DR   CLO; CLO_0050049
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03472088
DR   BioSample; SAMN10988374
DR   cancercelllines; CVCL_4900
DR   Cell_Model_Passport; SIDM01767
DR   CGH-DB; 192-1
DR   CGH-DB; 9181-4
DR   Cosmic; 889087
DR   Cosmic; 946075
DR   Cosmic; 1048222
DR   Cosmic; 1066172
DR   Cosmic; 1219090
DR   Cosmic; 1239913
DR   Cosmic; 2060523
DR   DepMap; ACH-000553
DR   GEO; GSM887647
DR   GEO; GSM888739
DR   IARC_TP53; 28446
DR   IARC_TP53; 30172
DR   LiGeA; CCLE_756
DR   PharmacoDB; Sq1_1494_2019
DR   Progenetix; CVCL_4900
DR   RCB; RCB1905
DR   TKG; TKG 0301
DR   Wikidata; Q54955595
RX   PubMed=9023415;
RX   PubMed=9416778;
RX   PubMed=9538136;
RX   PubMed=14581340;
RX   PubMed=15746151;
RX   PubMed=16105816;
RX   PubMed=17511773;
RX   PubMed=19472407;
RX   PubMed=20557307;
RX   PubMed=22460905;
RX   PubMed=24002593;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=38639832;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   HLA typing: A*11:01,24:02; B*15:01,52:01; C*04:01,12:02 (PubMed=9023415).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous; Note=In 10% of cells (PubMed=16105816).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.375+2T>C (IVS4+2T>C); ClinVar=VCV000439316; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=20557307; DepMap=ACH-000553).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.4%; Native American=0%; East Asian, North=81.37%; East Asian, South=17.66%; South Asian=0.56%; European, North=0%; European, South=0% (PubMed=30894373).
ST   Source(s): RCB=RCB1905; TKG=TKG 0301
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 8
ST   D16S539: 9,12
ST   D5S818: 12,13
ST   D7S820: 8,13
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 19
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki, Naoko
RA   Hoshino, Tomoaki
RA   Kikuchi, Megumi
RA   Hayashi, Akihiro
RA   Itoh, Kyogo
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa, Reika
RA   Kohno, Takashi
RA   Enari, Masatoshi
RA   Kiyono, Tohru
RA   Yokota, Jun
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai, Yoshiaki
RA   Miyazawa, Hitoshi
RA   No_last_name, Huqun
RA   Tanaka, Tomoaki
RA   Udagawa, Kiyoshi
RA   Kato, Motoyasu
RA   Fukuyama, Shunichiro
RA   Yokote, Akemi
RA   Kobayashi, Kunihiko
RA   Kanazawa, Minoru
RA   Hagiwara, Koichi
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=9416778; DOI=10.1016/S0024-3205(97)01010-2;
RA   Shoji, Masaru
RA   Kimura, Tokihisa
RA   Ota, Kozo
RA   Yamaji, Tohru
RA   Ishibashi, Miyuki
RA   Ohta, Masahiro
RA   Sasano, Hironobu
RA   Kawarabayasi, Yutaka
RA   Kimura, Noriko
RA   Funyu, Takeharu
RA   Mori, Takefumi
RA   Sahata, Takayuki
RT   "Genotype analysis of prepro-vasopressin signal peptide in
RT   vasopressin-producing and -non-producing lung tumors.";
RL   Life Sci. 61:2561-2566(1997).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702;
RA   Fukuyama, Takashi
RA   Ichiki, Yoshinobu
RA   Yamada, Sousuke
RA   Shigematsu, Yoshiki
RA   Baba, Tetsuro
RA   Nagata, Yoshika
RA   Mizukami, Makiko
RA   Sugaya, Masakazu
RA   Takenoyama, Mitsuhiro
RA   Hanagiri, Takeshi
RA   Sugio, Kenji
RA   Yasumoto, Kosei
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin Karl
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210;
RA   Kasai, Fumio
RA   Fukushima, Makoto
RA   Miyagi, Yohei
RA   Nakamura, Yukio
RT   "Genetic diversity among the present Japanese population: evidence
RT   from genotyping of human cell lines established in Japan.";
RL   Hum. Cell 37:944-950(2024).
//
RX   PubMed=15746151; DOI=10.1093/hmg/ddi092;
RA   Izumi, Hiroto
RA   Inoue, Jun
RA   Yokoi, Sana
RA   Hosoda, Hiroshi
RA   Shibata, Tatsuhiro
RA   Sunamori, Makoto
RA   Hirohashi, Setsuo
RA   Inazawa, Johji
RA   Imoto, Issei
RT   "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in
RT   non-small cell lung cancers.";
RL   Hum. Mol. Genet. 14:997-1007(2005).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco, Raquel
RA   Iwakawa, Reika
RA   Tang, Mo-Ying
RA   Kohno, Takashi
RA   Angulo, Barbara
RA   Pio, Ruben
RA   Montuenga, Luis M.
RA   Minna, John D.
RA   Yokota, Jun
RA   Sanchez-Cespedes, Montse
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=14581340;
RA   Yokoi, Sana
RA   Yasui, Kohichiroh
RA   Iizasa, Toshihiko
RA   Imoto, Issei
RA   Fujisawa, Takehiko
RA   Inazawa, Johji
RT   "TERC identified as a probable target within the 3q26 amplicon that is
RT   detected frequently in non-small cell lung cancers.";
RL   Clin. Cancer Res. 9:4705-4713(2003).
//
RX   PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976;
RA   Wu, Di
RA   Pang, Yi
RA   Wilkerson, Matthew D.
RA   Wang, Die
RA   Hammerman, Peter S.
RA   Liu, Jun S.
RT   "Gene-expression data integration to squamous cell lung cancer
RT   subtypes reveals drug sensitivity.";
RL   Br. J. Cancer 109:1599-1608(2013).
//
RX   PubMed=9538136; DOI=10.3892/ijo.12.5.1103;
RA   Takaki, Toshiyuki
RA   Hiraki, Akio
RA   Uenaka, Akiko
RA   Gomi, Shinya
RA   Itoh, Kyogo
RA   Udono, Heiichiro
RA   Shibuya, Akira
RA   Tsuji, Takao
RA   Sekiguchi, Sadayoshi
RA   Nakayama, Eiichi
RT   "Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3
RT   peptide recognized by cytotoxic T lymphocytes.";
RL   Int. J. Oncol. 12:1103-1109(1998).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//