ID   XG-2
AC   CVCL_4798
SY   XG2; XG 2
DR   ArrayExpress; E-TABM-937
DR   cancercelllines; CVCL_4798
DR   Cosmic; 742959
DR   Cosmic; 2081412
DR   Cosmic; 2367291
DR   Cosmic; 2809769
DR   IARC_TP53; 28497
DR   Wikidata; Q54994704
RX   CelloPub=CLPUB00604;
RX   DOI=10.1007/0-306-46877-8_4;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1373872;
RX   PubMed=1753108;
RX   PubMed=7504521;
RX   PubMed=8204890;
RX   PubMed=10557056;
RX   PubMed=10583232;
RX   PubMed=10936422;
RX   PubMed=16956823;
RX   PubMed=17692805;
RX   PubMed=18647998;
RX   PubMed=21173094;
RX   PubMed=30545397;
RX   PubMed=32123307;
WW   Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
CC   Characteristics: IL6 dependent.
CC   Characteristics: Produces IgG lambda.
CC   HLA typing: A*01,29; B*08,44; C*07,16:01 (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Unspecified (PubMed=21173094).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Tyr (c.527G>A); ClinVar=VCV000186451; Zygosity=Unspecified (PubMed=1373872; PubMed=21173094).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck, Catherine.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Plasma cell; CL=CL_0000786.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 28
//
RX   PubMed=10583232; DOI=10.1046/j.1365-2141.1999.01705.x;
RA   Puthier, Denis
RA   Derenne, Sophie
RA   Barille, Sophie
RA   Moreau, Philippe
RA   Harousseau, Jean-Luc
RA   Bataille, Francois-Regis
RA   Amiot, Martine
RT   "Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.";
RL   Br. J. Haematol. 107:392-395(1999).
//
RX   CelloPub=CLPUB00604;
RA   Chow, Sharon
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017); University of Toronto; Toronto; Canada.
//
RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler, Hans Gunther
RA   Matsuo, Yoshinobu
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
//
RX   PubMed=10557056; DOI=10.1038/sj.leu.2401563;
RA   Yoshida, Shoko
RA   Nakazawa, Naozo
RA   Iida, Shinsuke
RA   Hayami, Yoshihito
RA   Sato, Shigeki
RA   Wakita, Atsushi
RA   Shimizu, Shiro
RA   Taniwaki, Masafumi
RA   Ueda, Ryuzo
RT   "Detection of MUM1/IRF4-IgH fusion in multiple myeloma.";
RL   Leukemia 13:1812-1816(1999).
//
RX   PubMed=16956823;
RA   Bataille, Francois-Regis
RA   Jego, Gaatan
RA   Robillard, Nelly
RA   Barille-Nion, Sophie
RA   Harousseau, Jean-Luc
RA   Moreau, Philippe
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "The phenotype of normal, reactive and malignant plasma cells.
RT   Identification of 'many and multiple myelomas' and of new targets for
RT   myeloma therapy.";
RL   Haematologica 91:1234-1240(2006).
//
RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300;
RA   Sarin, Vishesh
RA   Yu, Katharine
RA   Ferguson, Ian D.
RA   Gugliemini, Olivia
RA   Nix, Matthew A.
RA   Hann, Byron
RA   Sirota, Marina
RA   Wiita, Arun P.
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
//
RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund, Helena
RA   Nilsson, Kenneth
RT   "Multiple myeloma cell lines.";
RL   (In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698;
RA   Keats, Jonathan J.
RA   Fonseca, Rafael
RA   Chesi, Marta
RA   Schop, Roelandt
RA   Baker, Angela
RA   Chng, Wee-Joo
RA   Van Wier, Scott
RA   Tiedemann, Rodger
RA   Shi, Chang-Xin
RA   Sebag, Michael
RA   Braggio, Esteban
RA   Henry, Travis
RA   Zhu, Yuan-Xiao
RA   Fogle, Homer
RA   Price-Troska, Tammy L.
RA   Ahmann, Gregory J.
RA   Mancini, Catherine
RA   Brents, Leslie A.
RA   Kumar, Shaji K.
RA   Greipp, Philip Robert
RA   Dispenzieri, Angela
RA   Bryant, Barb
RA   Mulligan, George
RA   Bruhn, Laurakay
RA   Barrett, Michael T.
RA   Valdez, Riccardo
RA   Trent, Jeffrey M.
RA   Stewart, A. Keith
RA   Carpten, John D.
RA   Bergsagel, Peter Leif
RT   "Promiscuous mutations activate the noncanonical NF-kappaB pathway in
RT   multiple myeloma.";
RL   Cancer Cell 12:131-144(2007).
//
RX   PubMed=8204890; DOI=10.1182/blood.V83.12.3654.3654;
RA   Zhang, Xue-Guang
RA   Gaillard, Jean-Philippe
RA   Robillard, Nelly
RA   Lu, Zhao-Yang
RA   Gu, Zong-Jiang
RA   Jourdan, Michel
RA   Boiron, Jean-Michel
RA   Bataille, Francois-Regis
RA   Klein, Bernard
RT   "Reproducible obtaining of human myeloma cell lines as a model for
RT   tumor stem cell study in human multiple myeloma.";
RL   Blood 83:3654-3663(1994).
//
RX   PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184;
RA   Dib, Amel
RA   Gabrea, Ana
RA   Glebov, Oleg K.
RA   Bergsagel, Peter Leif
RA   Kuehl, Walter Michael
RT   "Characterization of MYC translocations in multiple myeloma cell
RT   lines.";
RL   J. Natl. Cancer Inst. Monogr. 39:25-31(2008).
//
RX   PubMed=1753108; DOI=10.4049/jimmunol.147.12.4402;
RA   Jourdan, Michel
RA   Zhang, Xue-Guang
RA   Portier, Marielle
RA   Boiron, Jean-Michel
RA   Bataille, Francois-Regis
RA   Klein, Bernard
RT   "IFN-alpha induces autocrine production of IL-6 in myeloma cell
RT   lines.";
RL   J. Immunol. 147:4402-4407(1991).
//
RX   PubMed=7504521; DOI=10.1002/gcc.2870080204;
RA   Raynaud, Sophie D.
RA   Bekri, Soumeya
RA   Leroux, Dominique
RA   Grosgeorge, Josiane
RA   Klein, Bernard
RA   Bastard, Christian
RA   Gaudray, Patrick
RA   Simon, Marie-Pierre
RT   "Expanded range of 11q13 breakpoints with differing patterns of cyclin
RT   D1 expression in B-cell malignancies.";
RL   Genes Chromosomes Cancer 8:80-87(1993).
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235;
RA   Moreaux, Jerome
RA   Klein, Bernard
RA   Bataille, Francois-Regis
RA   Descamps, Geraldine
RA   Maiga, Sophie
RA   Hose, Dirk
RA   Goldschmidt, Hartmut
RA   Jauch, Anna
RA   Reme, Thierry
RA   Jourdan, Michel
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
//
RX   PubMed=1373872;
RA   Mazars, Georges-Raoul
RA   Portier, Marielle
RA   Zhang, Xue-Guang
RA   Jourdan, Michel
RA   Bataille, Francois-Regis
RA   Theillet, Charles
RA   Klein, Bernard
RT   "Mutations of the p53 gene in human myeloma cell lines.";
RL   Oncogene 7:1015-1018(1992).
//
RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660;
RA   Tessoulin, Benoit
RA   Moreau-Aubry, Agnes
RA   Descamps, Geraldine
RA   Gomez-Bougie, Patricia
RA   Maiga, Sophie
RA   Gaignard, Alban
RA   Chiron, David
RA   Menoret, Emmanuelle
RA   Le Gouill, Steven
RA   Moreau, Philippe
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137.1-137.13(2018).
//