ID   MX-1
AC   CVCL_4774
SY   MX1; MXI
DR   BTO; BTO_0004179
DR   CLO; CLO_0009915
DR   EFO; EFO_0006457
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03472921
DR   ChEMBL-Cells; CHEMBL3308046
DR   ChEMBL-Targets; CHEMBL613704
DR   CLS; 300296
DR   DepMap; ACH-002328
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   GEO; GSM844611
DR   GEO; GSM844612
DR   GEO; GSM844613
DR   GEO; GSM845398
DR   GEO; GSM1172893
DR   GEO; GSM1172987
DR   LINCS_HMS; 51090
DR   LINCS_LDP; LCL-2072
DR   NCI-DTP; MX-1
DR   PharmacoDB; MX1_973_2019
DR   PubChem_Cell_line; CVCL_4774
DR   Wikidata; Q54907134
RX   PubMed=10969801;
RX   PubMed=24176112;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=26589293;
RX   PubMed=29045385;
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Population: Caucasian.
CC   Characteristics: Established from a tumor xenograft established in atyhmic mice.
CC   Doubling time: 30-35 hours (CLS=300296); 113.83 hours (JWGray panel).
CC   HLA typing: A*11:01,74:01; B*15:03,35:01; C*02:02,04:01; DQB1*03:09,05:01; DRB1*01:03,11:08 (PubMed=25960936).
CC   HLA typing: A*11:01,74:01; B*15:03,35:01; C*02:02,04:01; DRB1*01:03,01:03 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln52Valfs*3 (c.154_158delCAATG); Zygosity=Unspecified (PubMed=29045385).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
ST   Source(s): CLS=300296; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11 (PubMed=25877200)
ST   D13S317: 11,12 (CLS=300296)
ST   D16S539: 12
ST   D18S51: 12,16
ST   D19S433: 13,15.2,16.2
ST   D21S11: 29,30,31,32 (CLS=300296)
ST   D21S11: 29,32 (PubMed=25877200)
ST   D2S1338: 19
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 11 (PubMed=25877200)
ST   D7S820: 11,12 (CLS=300296)
ST   D8S1179: 11 (PubMed=25877200)
ST   D8S1179: 11,12,13 (CLS=300296)
ST   FGA: 20
ST   Penta D: 6,9,11
ST   Penta E: 14
ST   TH01: 7,9
ST   TPOX: 7,8 (CLS=300296)
ST   TPOX: 8 (PubMed=25877200)
ST   vWA: 17 (PubMed=25877200)
ST   vWA: 17,18 (CLS=300296)
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   29Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=10969801;
RA   Forozan, Farahnaz
RA   Mahlamaki, Eija H.
RA   Monni, Outi
RA   Chen, Yi-Dong
RA   Veldman, Robin
RA   Jiang, Yuan
RA   Gooden, Gerald C.
RA   Ethier, Stephen P.
RA   Kallioniemi, Anne H.
RA   Kallioniemi, Olli-Pekka
RT   "Comparative genomic hybridization analysis of 38 breast cancer cell
RT   lines: a basis for interpreting complementary DNA microarray data.";
RL   Cancer Res. 60:4519-4525(2000).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary J.
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=29045385; DOI=10.1038/nature24006;
RA   Kategaya, Lorna
RA   Di Lello, Paola
RA   Rouge, Lionel
RA   Pastor, Richard M.
RA   Clark, Kevin R.
RA   Drummond, Jason
RA   Kleinheinz, Tracy
RA   Lin, Eva
RA   Upton, John-Paul
RA   Prakash, Sumit
RA   Heideker, Johanna
RA   McCleland, Mark L.
RA   Ritorto, Maria Stella
RA   Alessi, Dario Renato
RA   Trost, Matthias
RA   Bainbridge, Travis W.
RA   Kwok, Michael C.M.
RA   Ma, Taylur P.
RA   Stiffler, Zachary
RA   Brasher, Bradley
RA   Tang, Yin-Yan
RA   Jaishankar, Priyadarshini
RA   Hearn, Brian R.
RA   Renslo, Adam R.
RA   Arkin, Michelle Rose
RA   Cohen, Frederick
RA   Yu, Ke-Bing
RA   Peale, Franklin V.
RA   Gnad, Florian
RA   Chang, Matthew T.
RA   Klijn, Christiaan
RA   Blackwood, Elizabeth
RA   Martin, Scott E.
RA   Forrest, William F.
RA   Ernst, James A.
RA   Ndubaku, Chudi
RA   Wang, Xiao-Jing
RA   Beresini, Maureen H.
RA   Tsui, Vickie
RA   Schwerdtfeger, Carsten
RA   Blake, Robert A.
RA   Murray, Jeremy
RA   Maurer, Till
RA   Wertz, Ingrid E.
RT   "USP7 small-molecule inhibitors interfere with ubiquitin binding.";
RL   Nature 550:534-538(2017).
//