ID   ALVA-101
AC   CVCL_4735
SY   ALVA 101; ALVA101; American Lake VA-101
DR   BioSample; SAMN03151888
DR   cancercelllines; CVCL_4735
DR   Wikidata; Q54749372
RX   PubMed=1958578;
RX   PubMed=8561862;
RX   PubMed=9018337;
RX   PubMed=12725112;
RX   PubMed=14518029;
RX   PubMed=15643172;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=14518029; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00176.
CC   Population: Caucasian.
CC   Doubling time: 24 hours (PubMed=8561862).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0035 ! PC-3
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 25
RX   PubMed=1958578; DOI=10.1016/0960-0760(91)90309-S;
RA   Plymate S.R., Loop S.M., Hoop R.C., Wiren K.M., Ostenson R.C.,
RA   Hryb D.J., Rosner W.;
RT   "Effects of sex hormone binding globulin (SHBG) on human prostatic
RT   carcinoma.";
RL   J. Steroid Biochem. Mol. Biol. 40:833-839(1991).
RX   PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O;
RA   Mehta P.P., Lokeshwar B.L., Schiller P.C., Bendix M.V., Ostenson R.C.,
RA   Howard G.A., Roos B.A.;
RT   "Gap-junctional communication in normal and neoplastic prostate
RT   epithelial cells and its regulation by cAMP.";
RL   Mol. Carcinog. 15:18-32(1996).
RX   PubMed=9018337; DOI=10.1002/(SICI)1097-0045(19970101)30:1<58::AID-PROS9>3.0.CO;2-H;
RA   Webber M.M., Bello D., Quader S.T.A.;
RT   "Immortalized and tumorigenic adult human prostatic epithelial cell
RT   lines: characteristics and applications Part 2. Tumorigenic cell
RT   lines.";
RL   Prostate 30:58-64(1997).
RX   PubMed=12725112; DOI=10.1385/1-59259-372-0:21;
RA   Russell P.J., Kingsley E.A.;
RT   "Human prostate cancer cell lines.";
RL   Methods Mol. Med. 81:21-39(2003).
RX   PubMed=14518029; DOI=10.1002/pros.10290;
RA   van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U.,
RA   Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.;
RT   "Molecular characterization of human prostate carcinoma cell lines.";
RL   Prostate 57:205-225(2003).
RX   PubMed=15643172; DOI=10.1097/01.ju.0000141580.30910.57;
RA   Sobel R.E., Sadar M.D.;
RT   "Cell lines used in prostate cancer research: a compendium of old and
RT   new lines -- part 1.";
RL   J. Urol. 173:342-359(2005).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).