ID   ALVA-41
AC   CVCL_4734
SY   ALVA 41; ALVA41; American Lake VA-41
DR   BTO; BTO_0002006
DR   BioSample; SAMN03151890
DR   cancercelllines; CVCL_4734
DR   Wikidata; Q54749378
RX   CelloPub=CLPUB00698;
RX   PubMed=1958578;
RX   PubMed=7533340;
RX   PubMed=8561862;
RX   PubMed=11304728;
RX   PubMed=12725112;
RX   PubMed=15643172;
RX   PubMed=20143388;
WW   Info; CaP CLDb; -; https://web.archive.org/web/20160703200531/http://capcelllines.ca:80/details.asp?id=84
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=11304728; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from the bone metastasis in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00174.
CC   Population: Caucasian.
CC   Doubling time: 22-24 hours (PubMed=7533340); 20 hours (PubMed=8561862).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (PubMed=11304728).
CC   Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
ST   Source(s): PubMed=11304728
ST   Amelogenin: X
ST   D13S317: 11
ST   D18S51: 14,15
ST   D21S11: 29,31.2
ST   D3S1358: 16,17
ST   D5S818: 13,14
ST   D7S820: 8,11
ST   D8S1179: 13
ST   FGA: 24
ST   vWA: 17
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0035 ! PC-3
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
//
RX   PubMed=12725112; DOI=10.1385/1-59259-372-0:21;
RA   Russell, Pamela J.
RA   Kingsley, Elizabeth A.
RT   "Human prostate cancer cell lines.";
RL   Methods Mol. Med. 81:21-39(2003).
//
RX   CelloPub=CLPUB00698;
RA   van Bokhoven, Adrie
RT   "Models for prostate cancer. Molecular characterization and critical
RT   appraisal of human prostate carcinoma cell lines.";
RL   Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands.
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=1958578; DOI=10.1016/0960-0760(91)90309-S;
RA   Plymate, Stephen Rex
RA   Loop, Steven M.
RA   Hoop, Rita Caporicci
RA   Wiren, Kristine M.
RA   Ostenson, Richard C.
RA   Hryb, Daniel J.
RA   Rosner, William
RT   "Effects of sex hormone binding globulin (SHBG) on human prostatic
RT   carcinoma.";
RL   J. Steroid Biochem. Mol. Biol. 40:833-839(1991).
//
RX   PubMed=15643172; DOI=10.1097/01.ju.0000141580.30910.57;
RA   Sobel, Richard E.
RA   Sadar, Marianne D.
RT   "Cell lines used in prostate cancer research: a compendium of old and
RT   new lines -- part 1.";
RL   J. Urol. 173:342-359(2005).
//
RX   PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O;
RA   Mehta, Parmender P.
RA   Lokeshwar, Balakrishna L.
RA   Schiller, Paul C.
RA   Bendix, Marcelo V.
RA   Ostenson, Richard C.
RA   Howard, Guy A.
RA   Roos, Bernard A.
RT   "Gap-junctional communication in normal and neoplastic prostate
RT   epithelial cells and its regulation by cAMP.";
RL   Mol. Carcinog. 15:18-32(1996).
//
RX   PubMed=7533340; DOI=10.1016/0039-128X(94)90052-3;
RA   Nakhla, Atif M.
RA   Rosner, William
RT   "Characterization of ALVA-41 cells, a new human prostatic cancer cell
RT   line.";
RL   Steroids 59:586-589(1994).
//
RX   PubMed=11304728; DOI=10.1002/pros.1045;
RA   van Bokhoven, Adrie
RA   Varella-Garcia, Marileila
RA   Korch, Christopher T.
RA   Hessels, Daphne
RA   Miller, Gary J.
RT   "Widely used prostate carcinoma cell lines share common origins.";
RL   Prostate 47:36-51(2001).
//