ID   THP-8
AC   CVCL_4687
SY   Tohoku Hospital Pediatrics-8
DR   BTO; BTO_0004927
DR   Cosmic; 710462
DR   Cosmic; 801719
DR   Cosmic; 998705
DR   Cosmic; 1037731
DR   Wikidata; Q54972357
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2954268;
RX   PubMed=7727782;
RX   PubMed=8558913;
RX   PubMed=10233379;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: 68 hours (PubMed=2954268).
CC   Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   7M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 18
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=2954268; DOI=10.1620/tjem.151.283;
RA   Minegishi M., Tsuchiya S., Minegishi N., Konno T.;
RT   "Establishment of five human malignant non-T lymphoid cell lines and
RT   mixed lymphocyte-tumor reaction.";
RL   Tohoku J. Exp. Med. 151:283-292(1987).
//
RX   PubMed=7727782; DOI=10.1182/blood.V85.9.2546.bloodjournal8592546;
RA   Kawamura M., Kikuchi A., Kobayashi S., Hanada R., Yamamoto K.,
RA   Horibe K., Shikano T., Ueda K., Hayashi K., Sekiya T., Hayashi Y.;
RT   "Mutations of the p53 and ras genes in childhood t(1;19)-acute
RT   lymphoblastic leukemia.";
RL   Blood 85:2546-2552(1995).
//
RX   PubMed=8558913;
RA   Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M.,
RA   Imaizumi M., Endo M., Takano N., Konno T.;
RT   "Cell surface c-kit receptors in human leukemia cell lines and
RT   pediatric leukemia: selective preservation of c-kit expression on
RT   megakaryoblastic cell lines during adaptation to in vitro culture.";
RL   Leukemia 10:102-105(1996).
//
RX   PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x;
RA   Xu F., Taki T., Yang H.W., Hanada R., Hongo T., Ohnishi H.,
RA   Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.;
RT   "Tandem duplication of the FLT3 gene is found in acute lymphoblastic
RT   leukaemia as well as acute myeloid leukaemia but not in
RT   myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in
RT   children.";
RL   Br. J. Haematol. 105:155-162(1999).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Corrigendum to: Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24
RT   (2000), 255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//