ID   OE47
AC   CVCL_4627
SY   OE-47; JROECL 47; JROECL47
DR   CLO; CLO_0008241
DR   CLDB; cl3763
DR   cancercelllines; CVCL_4627
DR   Cosmic; 997862
DR   ECACC; 96061336
DR   Wikidata; Q54931866
RX   PubMed=9010035;
RX   PubMed=10789716;
RX   PubMed=23795680;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (PubMed=10789716). Originally thought to originate from a 76 year old male patient with an esophageal squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00546.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: ECACC; 96061336; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=23795680; DOI=10.1111/dote.12095;
RA   Boonstra, Jurjen J.
RA   Tilanus, Hugo W.
RA   Dinjens, Winand N.M.
RT   "Translational research on esophageal adenocarcinoma: from cell line
RT   to clinic.";
RL   Dis. Esophagus 28:90-96(2015).
//
RX   PubMed=10789716; DOI=10.1054/bjoc.1999.1170; PMCID=PMC2363398;
RA   Wijnhoven, Bas P.L.
RA   Tilanus, Marcel G.J.
RA   Morris, Alan G.
RA   Darnton, S. Jane
RA   Tilanus, Hugo W.
RA   Dinjens, Winand N.M.
RT   "Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50
RT   are admixtures of the human colon carcinoma cell line HCT 116.";
RL   Br. J. Cancer 82:1510-1512(2000).
//
RX   PubMed=9010035; DOI=10.1038/bjc.1997.42; PMCID=PMC2063267;
RA   Rockett, John C.
RA   Larkin, K.
RA   Darnton, S. Jane
RA   Morris, Alan G.
RA   Matthews, Hugoe R.
RT   "Five newly established oesophageal carcinoma cell lines: phenotypic
RT   and immunological characterization.";
RL   Br. J. Cancer 75:258-263(1997).
//