ID   RF/6A
AC   CVCL_4552
DR   CLO; CLO_0008790
DR   ATCC; CRL-1780
DR   BCRC; 60558
DR   ChEMBL-Cells; CHEMBL4513118
DR   ChEMBL-Targets; CHEMBL4513132
DR   CLS; 305150
DR   GEO; GSE113674
DR   Lonza; 1179
DR   PubChem_Cell_line; CVCL_4552
DR   Wikidata; Q54949809
RX   PubMed=3102454;
RX   PubMed=3771439;
RX   PubMed=27259688;
RX   PubMed=30508043;
CC   Group: Non-human primate cell line.
CC   Problematic cell line: Probably misidentified. While originally thought to be an endothelial cell line, it has been shown to lack functional and transcriptomic characteristics of such cell type (PubMed=30508043).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Fetal eye, choroid; UBERON=UBERON_0010312+UBERON_0001776.
CC   Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
OX   NCBI_TaxID=9544; ! Macaca mulatta (Rhesus macaque)
SX   Sex unspecified
AG   64FD
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 19
//
RX   PubMed=3102454; DOI=10.1007/BF02623586;
RA   Lou D.-A., Hu F.-N.;
RT   "Specific antigen and organelle expression of a long-term rhesus
RT   endothelial cell line.";
RL   In Vitro Cell. Dev. Biol. 23:75-85(1987).
//
RX   PubMed=3771439; DOI=10.1007/BF02623517;
RA   Hu F.-N., Mah K., Teramura D.J.;
RT   "Gossypol effects on cultured normal and malignant melanocytes.";
RL   In Vitro Cell. Dev. Biol. 22:583-588(1986).
//
RX   PubMed=27259688; DOI=10.3109/02713683.2016.1145234;
RA   Li R., Du J.-H., Chang Y.;
RT   "Role of autophagy in hypoxia-induced angiogenesis of RF/6A cells in
RT   vitro.";
RL   Curr. Eye Res. 41:1566-1570(2016).
//
RX   PubMed=30508043; DOI=10.1167/iovs.18-25215;
RA   Makin R.D., Apicella I., Nagasaka Y., Kaneko H., Turner S.D.,
RA   Kerur N., Ambati J., Gelfand B.D.;
RT   "RF/6A chorioretinal cells do not display key endothelial
RT   phenotypes.";
RL   Invest. Ophthalmol. Vis. Sci. 59:5795-5802(2018).
//