ID   LIM2412
AC   CVCL_4439
SY   Lim2412; LIM 2412; LIM-2412
DR   BTO; BTO_0001917
DR   cancercelllines; CVCL_4439
DR   ColonAtlas; LIM2412
DR   Cosmic; 1482519
DR   Cosmic; 1524340
DR   Cosmic; 2667974
DR   GEO; GSM741245
DR   GEO; GSM1448075
DR   Wikidata; Q54902534
RX   PubMed=1427983;
RX   PubMed=12615714;
RX   PubMed=25926053;
CC   From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
CC   Doubling time: 30 hours (PubMed=1427983).
CC   Microsatellite instability: Instable (MSI) (PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (PubMed=12615714).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (PubMed=12615714).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 9
ST   D13S317: 8,13
ST   D16S539: 11,12
ST   D21S11: 28,29,30
ST   D5S818: 10
ST   D7S820: 8,11
ST   TH01: 6
ST   TPOX: 7,8,9
ST   vWA: 14,17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
//
RX   PubMed=1427983; DOI=10.1038/icb.1992.30;
RA   Whitehead R.H., Zhang H.H., Hayward I.P.;
RT   "Retention of tissue-specific phenotype in a panel of colon carcinoma
RT   cell lines: relationship to clinical correlates.";
RL   Immunol. Cell Biol. 70:227-236(1992).
//
RX   PubMed=12615714;
RA   Hempen P.M., Zhang L., Bansal R.K., Iacobuzio-Donahue C.A.,
RA   Murphy K.M., Maitra A., Vogelstein B., Whitehead R.H., Markowitz S.D.,
RA   Willson J.K.V., Yeo C.J., Hruban R.H., Kern S.E.;
RT   "Evidence of selection for clones having genetic inactivation of the
RT   activin A type II receptor (ACVR2) gene in gastrointestinal cancers.";
RL   Cancer Res. 63:994-999(2003).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//