ID   RERF-LC-A1
AC   CVCL_4402
SY   RERF-LC-AI; RERF-LCAI; RERFLCAI; AOI; Radiation Effects Research Foundation-Lung Cancer-AI
DR   BTO; BTO_0006227
DR   CLO; CLO_0050027
DR   EFO; EFO_0002850
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 481
DR   BioSample; SAMN03472317
DR   BioSample; SAMN10987780
DR   cancercelllines; CVCL_4402
DR   Cell_Model_Passport; SIDM00307
DR   ChEMBL-Cells; CHEMBL3307414
DR   ChEMBL-Targets; CHEMBL614633
DR   Cosmic; 934471
DR   Cosmic; 946074
DR   Cosmic; 1048225
DR   Cosmic; 1089229
DR   Cosmic; 1571723
DR   Cosmic; 2060524
DR   Cosmic; 2645025
DR   DepMap; ACH-000261
DR   FANTOM5_SSTAR; 10501-107C6
DR   GEO; GSM887534
DR   GEO; GSM888616
DR   IARC_TP53; 18791
DR   IARC_TP53; 21634
DR   IARC_TP53; 30152
DR   LiGeA; CCLE_053
DR   PharmacoDB; RERFLCAI_1303_2019
DR   Progenetix; CVCL_4402
DR   PubChem_Cell_line; CVCL_4402
DR   RCB; RCB0444
DR   Wikidata; Q54949758
RX   PubMed=7790314;
RX   PubMed=7834619;
RX   PubMed=9023415;
RX   PubMed=9538136;
RX   PubMed=11416159;
RX   PubMed=12794755;
RX   PubMed=15901131;
RX   PubMed=16105816;
RX   PubMed=17511773;
RX   PubMed=21559605;
RX   PubMed=22460905;
RX   PubMed=22576795;
RX   PubMed=24002593;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=38639832;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Chinese; Taiwan.
CC   HLA typing: A*24:02; B*52:01; C*12:02 (PubMed=9023415).
CC   HLA typing: A*24:02,24:02; B*35:06,52:01; C*12:02,12:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Unspecified (PubMed=16105816).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln104Ter (c.310C>T); ClinVar=VCV000566924; Zygosity=Homozygous (PubMed=12794755; PubMed=15901131; DepMap=ACH-000261).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.35%; Native American=0%; East Asian, North=91.19%; East Asian, South=6.87%; South Asian=0.45%; European, North=1.14%; European, South=0% (PubMed=30894373).
CC   Misspelling: PERF-LC-AI; PubMed=12794755.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=11416159; RCB=RCB0444
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 10
ST   D18S51: 21
ST   D21S11: 29,32.2
ST   D5S818: 11
ST   D7S820: 8,12
ST   D8S1179: 12,14
ST   FGA: 25
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 33
CH   CVCL_1237 ! GT3TKB
CH   CVCL_D2U4 ! RERF-LC-A1/hPDPN
//
RX   PubMed=15901131; DOI=10.1016/j.prp.2005.01.002;
RA   Murai, Yoshihiro
RA   Hayashi, Shinichi
RA   Takahashi, Hiroyuki
RA   Tsuneyama, Koichi
RA   Takano, Yasuo
RT   "Correlation between DNA alterations and p53 and p16 protein
RT   expression in cancer cell lines.";
RL   Pathol. Res. Pract. 201:109-115(2005).
//
RX   PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976;
RA   Wu, Di
RA   Pang, Yi
RA   Wilkerson, Matthew D.
RA   Wang, Die
RA   Hammerman, Peter S.
RA   Liu, Jun S.
RT   "Gene-expression data integration to squamous cell lung cancer
RT   subtypes reveals drug sensitivity.";
RL   Br. J. Cancer 109:1599-1608(2013).
//
RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki, Naoko
RA   Hoshino, Tomoaki
RA   Kikuchi, Megumi
RA   Hayashi, Akihiro
RA   Itoh, Kyogo
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai, Yoshiaki
RA   Miyazawa, Hitoshi
RA   No_last_name, Huqun
RA   Tanaka, Tomoaki
RA   Udagawa, Kiyoshi
RA   Kato, Motoyasu
RA   Fukuyama, Shunichiro
RA   Yokote, Akemi
RA   Kobayashi, Kunihiko
RA   Kanazawa, Minoru
RA   Hagiwara, Koichi
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
//
RX   PubMed=12794755; DOI=10.1002/ijc.11184;
RA   Endoh, Hideki
RA   Yatabe, Yasushi
RA   Shimizu, Shigeki
RA   Tajima, Kohei
RA   Kuwano, Hiroyuki
RA   Takahashi, Takashi
RA   Mitsudomi, Tetsuya
RT   "RASSF1A gene inactivation in non-small cell lung cancer and its
RT   clinical implication.";
RL   Int. J. Cancer 106:45-51(2003).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210;
RA   Kasai, Fumio
RA   Fukushima, Makoto
RA   Miyagi, Yohei
RA   Nakamura, Yukio
RT   "Genetic diversity among the present Japanese population: evidence
RT   from genotyping of human cell lines established in Japan.";
RL   Hum. Cell 37:944-950(2024).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=21559605; DOI=10.3892/ijo.5.3.501;
RA   Teraoka, Seigo
RA   Kyoizumi, Seishi
RA   Seyama, Toshio
RA   Yamakido, Michio
RA   Akiyama, Mitoshi
RT   "Scid mice model for the in-vivo study of human oncotherapy -- studies
RT   on the growth and metastasis of human lung-cancer.";
RL   Int. J. Oncol. 5:501-508(1994).
//
RX   PubMed=9538136; DOI=10.3892/ijo.12.5.1103;
RA   Takaki, Toshiyuki
RA   Hiraki, Akio
RA   Uenaka, Akiko
RA   Gomi, Shinya
RA   Itoh, Kyogo
RA   Udono, Heiichiro
RA   Shibuya, Akira
RA   Tsuji, Takao
RA   Sekiguchi, Sadayoshi
RA   Nakayama, Eiichi
RT   "Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3
RT   peptide recognized by cytotoxic T lymphocytes.";
RL   Int. J. Oncol. 12:1103-1109(1998).
//
RX   PubMed=7790314; DOI=10.1111/j.1349-7006.1995.tb03073.x; PMCID=PMC5920855;
RA   Teraoka, Seigo
RA   Kyoizumi, Seishi
RA   Seyama, Toshio
RA   Yamakido, Michio
RA   Akiyama, Mitoshi
RT   "A novel SCID mouse model for studying spontaneous metastasis of human
RT   lung cancer to human tissue.";
RL   Jpn. J. Cancer Res. 86:419-423(1995).
//
RX   PubMed=7834619;
RA   Washimi, Osuke
RA   Nagatake, Masaaki
RA   Osada, Hirotaka
RA   Ueda, Ryuzo
RA   Koshikawa, Takashi
RA   Seki, Tsuneo
RA   Takahashi, Toshitada
RA   Takahashi, Takashi
RT   "In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations
RT   preferentially in non-small cell lung cancers.";
RL   Cancer Res. 55:514-517(1995).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters, John R.W.
RA   Thomson, Jim A.
RA   Daly-Burns, Bernadette
RA   Reid, Yvonne A.
RA   Dirks, Wilhelm Gerhard
RA   Packer, Phil
RA   Toji, Lorraine Hellenga
RA   Ohno, Tadao
RA   Tanabe, Hideyuki
RA   Arlett, Colin Francis
RA   Kelland, Lloyd R.
RA   Harrison, Maureen
RA   Virmani, Arvind K.
RA   Ward, Timothy H.
RA   Ayres, Karen L.
RA   Debenham, Paul G.
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702;
RA   Fukuyama, Takashi
RA   Ichiki, Yoshinobu
RA   Yamada, Sousuke
RA   Shigematsu, Yoshiki
RA   Baba, Tetsuro
RA   Nagata, Yoshika
RA   Mizukami, Makiko
RA   Sugaya, Masakazu
RA   Takenoyama, Mitsuhiro
RA   Hanagiri, Takeshi
RA   Sugio, Kenji
RA   Yasumoto, Kosei
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=22576795; DOI=10.3892/or.2012.1763;
RA   Ashinuma, Hironori
RA   Takiguchi, Yuichi
RA   Kitazono, Satoru
RA   Kitazono-Saitoh, Miyako
RA   Kitamura, Atsushi
RA   Chiba, Tetsuhiro
RA   Tada, Yuji
RA   Kurosu, Katsushi
RA   Sakaida, Emiko
RA   Sekine, Ikuo
RA   Tanabe, Nobuhiro
RA   Iwama, Atsushi
RA   Yokosuka, Osamu
RA   Tatsumi, Koichiro
RT   "Antiproliferative action of metformin in human lung cancer cell
RT   lines.";
RL   Oncol. Rep. 28:8-14(2012).
//