ID   OP9
AC   CVCL_4398
SY   OP-9
DR   BTO; BTO:0003295
DR   CLO; CLO_0008268
DR   ATCC; CRL-2749
DR   BCRC; 60566
DR   BCRJ; 0309
DR   CCRID; 1101MOU-PUMC000479
DR   CCRID; 3101MOUGNM17
DR   CCRID; 3101MOUSCSP227
DR   CLS; 305174
DR   GEO; GSM562062
DR   RCB; RCB1124
DR   Wikidata; Q50871278
RX   PubMed=8066449;
RX   PubMed=8990620;
RX   PubMed=20659712;
RX   PubMed=20810995;
RX   PubMed=23469264;
RX   PubMed=28176856;
WW   https://en.wikipedia.org/wiki/OP9_cell
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=op9
CC   Characteristics: Does not produce Csf1 (M-CSF) due to a mutation in the gene.
CC   Characteristics: Used as feeder cells for the differentiation of ES cells and iPS cells into hematopoietic cells.
CC   Doubling time: ~26 hours (ATCC=CRL-2749).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mesenchymal stem cell of bone marrow; CL=CL_0002540.
CC   Breed/subspecies: (C57BL/6 x C3H) F2-op/op.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   Embryo
CA   Stromal cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=8066449; DOI=10.1126/science.8066449;
RA   Nakano T., Kodama H., Honjo T.;
RT   "Generation of lymphohematopoietic cells from embryonic stem cells in
RT   culture.";
RL   Science 265:1098-1101(1994).
//
RX   PubMed=8990620;
RA   Nakano T.;
RT   "In vitro development of hematopoietic system from mouse embryonic
RT   stem cells: a new approach for embryonic hematopoiesis.";
RL   Int. J. Hematol. 65:1-8(1996).
//
RX   PubMed=20659712; DOI=10.1016/S1673-8527(09)60067-9;
RA   Gao J., Yan X.-L., Li R., Liu Y., He W.-Y., Sun S.-K., Zhang Y., Liu B.,
RA   Xiong J.-X., Mao N.;
RT   "Characterization of OP9 as authentic mesenchymal stem cell line.";
RL   J. Genet. Genomics 37:475-482(2010).
//
RX   PubMed=20810995; DOI=10.4049/jimmunol.1000195;
RA   Murata A., Okuyama K., Sakano S., Kajiki M., Hirata T., Yagita H.,
RA   Zuniga-Pflucker J.C., Miyake K., Akashi-Takamura S., Moriwaki S.,
RA   Niida S., Yoshino M., Hayashi S.-i.;
RT   "A Notch ligand, Delta-like 1 functions as an adhesion molecule for
RT   mast cells.";
RL   J. Immunol. 185:3905-3912(2010).
//
RX   PubMed=23469264; DOI=10.1371/journal.pone.0058123;
RA   Matsubara Y., Ono Y., Suzuki H., Arai F., Suda T., Murata M.,
RA   Ikeda Y.;
RT   "OP9 bone marrow stroma cells differentiate into megakaryocytes and
RT   platelets.";
RL   PLoS ONE 8:E58123-E58123(2013).
//
RX   PubMed=28176856; DOI=10.1038/srep42104;
RA   Kassotis C.D., Masse L., Kim S., Schlezinger J.J., Webster T.F.,
RA   Stapleton H.M.;
RT   "Characterization of adipogenic chemicals in three different cell
RT   culture systems: implications for reproducibility based on cell source
RT   and handling.";
RL   Sci. Rep. 7:42104-42104(2017).
//