ID   OP9
AC   CVCL_4398
SY   OP-9
DR   BTO; BTO_0003295
DR   CLO; CLO_0008268
DR   ATCC; CRL-2749
DR   BCRC; 60566
DR   BCRJ; 0309
DR   CCRID; 1101MOU-PUMC000479
DR   CCRID; 3101MOUGNM17
DR   CCRID; 3101MOUSCSP227
DR   CLS; 305174
DR   GEO; GSM562062
DR   RCB; RCB1124
DR   Wikidata; Q50871278
RX   PubMed=8066449;
RX   PubMed=8990620;
RX   PubMed=20659712;
RX   PubMed=20810995;
RX   PubMed=23469264;
RX   PubMed=28176856;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=op9
WW   Info; Wikipedia; -; https://en.wikipedia.org/wiki/OP9_cell
CC   Characteristics: Does not produce Csf1 (M-CSF) due to a mutation in the gene.
CC   Characteristics: Used as feeder cells for the differentiation of ES cells and iPS cells into hematopoietic cells.
CC   Doubling time: ~26 hours (ATCC=CRL-2749).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mesenchymal stem cell of bone marrow; CL=CL_0002540.
CC   Breed/subspecies: (C57BL/6 x C3H) F2-op/op.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   Embryo
CA   Stromal cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
CH   CVCL_HC57 ! OP-9S
CH   CVCL_KB57 ! OP9-K
CH   CVCL_B217 ! OP9/G
CH   CVCL_B218 ! OP9/G-DLL1
CH   CVCL_B219 ! OP9/N
//
RX   PubMed=20810995; DOI=10.4049/jimmunol.1000195;
RA   Murata, Akihiko
RA   Okuyama, Kazuki
RA   Sakano, Seiji
RA   Kajiki, Masahiro
RA   Hirata, Tomohisa
RA   Yagita, Hideo
RA   Zuniga-Pflucker, Juan Carlos
RA   Miyake, Kensuke
RA   Akashi-Takamura, Sachiko
RA   Moriwaki, Sawako
RA   Niida, Shumpei
RA   Yoshino, Miya
RA   Hayashi, Shin-ichi
RT   "A Notch ligand, Delta-like 1 functions as an adhesion molecule for
RT   mast cells.";
RL   J. Immunol. 185:3905-3912(2010).
//
RX   PubMed=20659712; DOI=10.1016/S1673-8527(09)60067-9;
RA   Gao, Jiao
RA   Yan, Xin-Long
RA   Li, Ren
RA   Liu, Yi
RA   He, Wen-Yan
RA   Sun, Sheng-Kun
RA   Zhang, Yu
RA   Liu, Bing
RA   Xiong, Jia-Xiang
RA   Mao, Ning
RT   "Characterization of OP9 as authentic mesenchymal stem cell line.";
RL   J. Genet. Genomics 37:475-482(2010).
//
RX   PubMed=23469264; DOI=10.1371/journal.pone.0058123; PMCID=PMC3585802;
RA   Matsubara, Yumiko
RA   Ono, Yukako
RA   Suzuki, Hidenori
RA   Arai, Fumio
RA   Suda, Toshio
RA   Murata, Mitsuru
RA   Ikeda, Yasuo
RT   "OP9 bone marrow stroma cells differentiate into megakaryocytes and
RT   platelets.";
RL   PLoS ONE 8:e58123.1-e58123.9(2013).
//
RX   PubMed=28176856; DOI=10.1038/srep42104; PMCID=PMC5296734;
RA   Kassotis, Christopher D.
RA   Masse, Lauren
RA   Kim, Stephanie
RA   Schlezinger, Jennifer Joy
RA   Webster, Thomas F.
RA   Stapleton, Heather M.
RT   "Characterization of adipogenic chemicals in three different cell
RT   culture systems: implications for reproducibility based on cell source
RT   and handling.";
RL   Sci. Rep. 7:42104.1-42104.17(2017).
//
RX   PubMed=8066449; DOI=10.1126/science.8066449;
RA   Nakano, Toru
RA   Kodama, Hiroaki
RA   Honjo, Tasuku
RT   "Generation of lymphohematopoietic cells from embryonic stem cells in
RT   culture.";
RL   Science 265:1098-1101(1994).
//
RX   PubMed=8990620; DOI=10.1016/s0925-5710(96)00531-2;
RA   Nakano, Toru
RT   "In vitro development of hematopoietic system from mouse embryonic
RT   stem cells: a new approach for embryonic hematopoiesis.";
RL   Int. J. Hematol. 65:1-8(1996).
//