ID   RWP-2
AC   CVCL_4374
SY   RWP 2; RWP2; Roger Williams Pancreatic-2
DR   cancercelllines; CVCL_4374
DR   Cosmic; 948730
DR   IARC_TP53; 3384
DR   Wikidata; Q54951496
RX   PubMed=7083162;
RX   PubMed=8026879;
RX   PubMed=9665481;
CC   Doubling time: 46 hours (PubMed=7083162; PubMed=8026879).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=8026879).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=8026879).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C8294; Pancreatic adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   40Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 16
//
RX   PubMed=7083162;
RA   Dexter D.L., Matook G.M., Meitner P.A., Bogaars H.A., Jolly G.A.,
RA   Turner M.D., Calabresi P.;
RT   "Establishment and characterization of two human pancreatic cancer
RT   cell lines tumorigenic in athymic mice.";
RL   Cancer Res. 42:2705-2714(1982).
//
RX   PubMed=8026879; DOI=10.1002/ijc.2910580207;
RA   Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.;
RT   "Comparative analysis of mutations in the p53 and K-ras genes in
RT   pancreatic cancer.";
RL   Int. J. Cancer 58:185-191(1994).
//
RX   PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940;
RA   Paciucci R., Vila M.R., Adell T., Diaz V.M., Tora M., Nakamura T.,
RA   Real F.X.;
RT   "Activation of the urokinase plasminogen activator/urokinase
RT   plasminogen activator receptor system and redistribution of E-cadherin
RT   are associated with hepatocyte growth factor-induced motility of
RT   pancreas tumor cells overexpressing Met.";
RL   Am. J. Pathol. 153:201-212(1998).
//