ID   NCI-H1514
AC   CVCL_4363
SY   H1514; H-1514
DR   ATCC; CRL-5873
DR   BioSample; SAMN03152020
DR   BioSample; SAMN03472582
DR   Cosmic; 877223
DR   Cosmic; 877380
DR   Cosmic; 980949
DR   Cosmic; 1021876
DR   Cosmic; 1032419
DR   GEO; GSM794317
DR   IARC_TP53; 428
DR   Wikidata; Q54907817
RX   PubMed=1312696;
RX   PubMed=1565469;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=10949990;
RX   PubMed=11030152;
RX   PubMed=20143388;
RX   PubMed=20679594;
RX   PubMed=31803961;
CC   Problematic cell line: Misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00242.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu68Ter (c.202G>T); ClinVar=VCV000224551; Zygosity=Unspecified (PubMed=1312696; PubMed=1565469).
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: ATCC; CRL-5873; true.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC; PubMed=20679594
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11,12 (PubMed=20679594)
ST   D13S317: 12 (ATCC)
ST   D16S539: 11
ST   D5S818: 11
ST   D7S820: 9,12
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 17,21 (PubMed=20679594)
ST   vWA: 17,21,22 (ATCC)
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2641 ! NCI-BL1514
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 25
RX   PubMed=1312696;
RA   D'Amico D., Carbone D.P., Mitsudomi T., Nau M.M., Fedorko J.,
RA   Russell E., Johnson B., Buchhagen D.L., Bodner S.M., Phelps R.M.,
RA   Gazdar A.F., Minna J.D.;
RT   "High frequency of somatically acquired p53 mutations in small-cell
RT   lung cancer cell lines and tumors.";
RL   Oncogene 7:339-346(1992).
RX   PubMed=1565469;
RA   Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P.,
RA   Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F.,
RA   Linnoila R.I.;
RT   "Expression of mutant p53 proteins in lung cancer correlates with the
RT   class of p53 gene mutation.";
RL   Oncogene 7:743-749(1992).
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
RX   PubMed=10949990; DOI=10.1290/1071-2690(2000)036<0344:UOGDIC>2.0.CO;2;
RA   Durkin A.S., Cedrone E., Sykes G., Boles D., Reid Y.A.;
RT   "Utility of gender determination in cell line identity.";
RL   In Vitro Cell. Dev. Biol. Anim. 36:344-347(2000).
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=20679594; DOI=10.1093/jnci/djq279;
RA   Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.;
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
RX   PubMed=31803961; DOI=10.1002/jcb.29564;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).