ID   NCI-H1514
AC   CVCL_4363
SY   H1514; H-1514
DR   ATCC; CRL-5873
DR   BioSample; SAMN03152020
DR   BioSample; SAMN03472582
DR   cancercelllines; CVCL_4363
DR   Cosmic; 877223
DR   Cosmic; 877380
DR   Cosmic; 980949
DR   Cosmic; 1021876
DR   Cosmic; 1032419
DR   GEO; GSM794317
DR   IARC_TP53; 428
DR   Wikidata; Q54907817
RX   PubMed=1312696;
RX   PubMed=1565469;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=10949990;
RX   PubMed=11030152;
RX   PubMed=20143388;
RX   PubMed=20679594;
RX   PubMed=31803961;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (PubMed=20143388). Furthermore its STR profile is different from that of the cell line NCI-BL1514 (Cellosaurus=CVCL_2641) which is supposed to originate from the same individual, a 56 year old Caucasian woman.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00242.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu68Ter (c.202G>T); ClinVar=VCV000224551; Zygosity=Unspecified (PubMed=1312696; PubMed=1565469).
CC   Omics: Transcriptomics; Microarray.
CC   Discontinued: ATCC; CRL-5873; true.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC=CRL-5873; PubMed=20679594
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11,12 (PubMed=20679594)
ST   D13S317: 12 (ATCC=CRL-5873)
ST   D16S539: 11
ST   D5S818: 11
ST   D7S820: 9,12
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 17,21 (PubMed=20679594)
ST   vWA: 17,21,22 (ATCC=CRL-5873)
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474;
RA   Gazdar, Adi F.
RA   Girard, Luc
RA   Lockwood, William W.
RA   Lam, Wan L.
RA   Minna, John D.
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=1565469;
RA   Bodner, Sara M.
RA   Minna, John D.
RA   Jensen, Sandra M.
RA   D'Amico, Domenico
RA   Carbone, David P.
RA   Mitsudomi, Tetsuya
RA   Fedorko, Joseph
RA   Buchhagen, Dotothy L.
RA   Nau, Marion M.
RA   Gazdar, Adi F.
RA   Linnoila, Ritva Ilona
RT   "Expression of mutant p53 proteins in lung cancer correlates with the
RT   class of p53 gene mutation.";
RL   Oncogene 7:743-749(1992).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi, Sanjay
RA   Kubo, Akihito
RA   Oie, Herbert Kazuto
RA   Coxon, Amy B.
RA   Rehmatulla, Ahad
RA   Kaye, Frederic J.
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=1312696;
RA   D'Amico, Domenico
RA   Carbone, David P.
RA   Mitsudomi, Tetsuya
RA   Nau, Marion M.
RA   Fedorko, Joseph
RA   Russell, Edward
RA   Johnson, Britt
RA   Buchhagen, Dotothy L.
RA   Bodner, Sara M.
RA   Phelps, Ruby M.
RA   Gazdar, Adi F.
RA   Minna, John D.
RT   "High frequency of somatically acquired p53 mutations in small-cell
RT   lung cancer cell lines and tumors.";
RL   Oncogene 7:339-346(1992).
//
RX   PubMed=10949990; DOI=10.1290/1071-2690(2000)036<0344:UOGDIC>2.0.CO;2;
RA   Durkin, A. Scott
RA   Cedrone, Edward
RA   Sykes, Gregory R.
RA   Boles, Debra
RA   Reid, Yvonne A.
RT   "Utility of gender determination in cell line identity.";
RL   In Vitro Cell. Dev. Biol. Anim. 36:344-347(2000).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps, Ruby M.
RA   Johnson, Bruce E.
RA   Ihde, Daniel C.
RA   Gazdar, Adi F.
RA   Carbone, David P.
RA   McClintock, Patrick R.
RA   Linnoila, Ritva Ilona
RA   Matthews, Mary J.
RA   Bunn, Paul A. Jr.
RA   Carney, Desmond Niall
RA   Minna, John D.
RA   Mulshine, James L.
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson, Bruce E.
RA   Russell, Edward
RA   Simmons, Alfreda M.
RA   Phelps, Ruby M.
RA   Steinberg, Seth M.
RA   Ihde, Daniel C.
RA   Gazdar, Adi F.
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//